Abstract
Because of their central role in the regulation of energy-transduction, mitochondria, the major site of oxidative processes within the cell, are considered a likely subcellular target for the action that thyroid hormones exert on energy metabolism. However, the mechanism underlying the regulation of basal metabolic rate (BMR) by thyroid hormones still remains unclear. It has been suggested that these hormones might uncouple substrate oxidation from ATP synthesis, but there are no clear-cut data to support this idea. Two iodothyronines have been identified as effectors of the actions of thyroid hormones on energy metabolism: 3',3,5-triiodo-L-thyronine (T3) and 3,5-diiodo-L-thyronine (T2). Both have significant effects on BMR, but their mechanisms of action are not identical. T3 acts on the nucleus to influence the expression of genes involved in the regulation of cellular metabolism and mitochondria function; 3,5-T2, on the other hand, acts by directly influencing the mitochondrial energy-transduction apparatus. A molecular determinant of the effects of T3 could be uncoupling protein-3 (UCP-3), while the cytochrome-c oxidase complex is a possible target for 3,5-T2. In conclusion, it is likely that iodothyronines regulate energy metabolism by both short-term and long-term mechanisms, and that they act in more than one way in affecting mitochondrial functions.
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References
Adams, E.S. (1998). Territory size and shape in fire ants: a model based on neighbourhood interactions.- Ecology 79, p. 1125–1134.
Archer, J. (1988). The behavioural biology of aggression. - Cambridge University Press, Cambridge.
- - & Huntingford, F. (1994). Game theory models and escalation of animal fights. - In: The dynamics of aggression: biological and social processes in dyads and groups, (Potegal, M. & Knutson, J.F., eds). Hillsdale, New Jersey.
Bisazza, A., Vaccari, G. & Pilastro, A. (2001). Female mate choice in a mating system dominated by male sexual coercion.- Behav. Ecol. 12, p. 59–64.
Boinski, S. & Garber, P.A. (2000). On the move: how and why animals travel in groups.- University of Chicago Press, Chicago.
Bradbury, J.W. & Vehrencamp, S.L. (1998). Principles of animal communication.-Sinauer Associates, Sunderland, Mass.
Clutton-Brock, T.H. & Parker, G.A. (1995). Punishment in animal societies.- Nature 373, p. 209–216.
De Dreu, C.K.W., Weingart, L.R. & Kwon, S. (2000). Influence of social motives on integrative negotiation: a meta-analytic review and test of two theories.- J. Pers. Soc. Psych. 78, p. 889–905.
Eason, P. (1992). Optimization of territory shape in heterogeneous habitats- a field study of the red-capped cardinal (Paroaria gularis). - J. Anim. Ecol. 61, p. 411–424.
Fisher, R.A. (1954). Statistical methods for research workers.-Oliver & Boyd, Edinburgh.
Furness, R.W. (1987). The Skuas.- T. & A.D. Poyser, Staffordshire.
Gadagkar, R. (1997). Survival strategies: cooperation and conflict in animal societies. - Harvard University Press, Cambridge, Mass.
Gonzalez, E. & Osorno, J.L. (1987). Dinámica de la territorialidad en una colonia de bobo de patas azules, Sula nebouxii, en Isla Isabel, Nayarít, Mexico. - Unpubl. thesis, Universidad Nacional Autonoma de Mexico.
Gowaty, P. (1997). Sexual dialectics, sexual selection and variation in reproductive behaviour. - In: Feminism and evolutionary biology (P. Gowaty, ed.). Chapman & Hall, New York, p. 351–384.
Greenhalgh, L. & Chapman, D.I. (1995). Joint decisionmaking.-In: Negotiationas a social process (R.M. Kramer & D.M. Messick, eds). Sage, Thousand Oaks, California, p. 166–185.
Guerra, M. & Drummond, H. (1995). Reversed sexual size dimorphism and parental care: minimal division of labour in the blue-footed booby.- Behaviour 132, p. 479–496.
Hochberg, Y. (1988). A sharper Bonferroni procedure for multiple tests of significance. - Biometrika 75, p. 800–802.
Huntingford, F. & Turner, A. (1987). Animal conflict.-Chapman & Hall, London.
Kölliker, M. & Richner, H. (2001). Parent-offspring conflict and genetics of offspring solicitation and parental response.-Anim. Behav. 62, p. 395–407.
Krebs, J.R. & Davies, N.B. (1984). Behavioural ecology: an evolutionary approach. - Sinauer Associates, Sunderland, Mass.
Ligon, J.D. (1999). The evolution of avian breeding systems. - Oxford University Press, Oxford.
Marzluff, J.M. & Balda, R.P. (1992). The pinyon jay: behavioural ecology of a colonial and cooperative corvid.- Poyser, London.
Maynard Smith, J. (1991). Honest signaling- the Philip Sidney game.- Anim. Behav. 42, p. 1034–1035.
-- (1994). Must reliable signals always be costly.- Anim. Behav. 47, p. 1115–1120.
Murphy, E.C. & Schauer, J.H. (1996). Synchrony in egg-laying and reproductive success of neighboring common murres, Uria aalge. - Behav. Ecol. Sociobiol. 39, p. 245–258.
Nethersole-Thompson, D. & Nethersole-Thompson, M. (1979). Greenshanks. - Buteo Books, Vermillion, South Dakota.
Nelson, B. (1978). The Sulidae: gannets and boobies.- Oxford University Press, Oxford.
O'Connell, M.J., Coulson, J.C., Raven, S. & Joyce, S. (1997). Nonbreeding and nests without eggs in the lesser black-backed gull Larus fuscus - Ibis 139, p. 252–258.
Newton, I. (1986). The sparrowhawk.-T. & A.D. Poyser, Calton.
Prins, H.T. (1996). Ecology and behaviour of the African buffalo: social inequality and decision making.- Chapman and Hall, New York.
Pruitt, D.G. (1981). Negotiation behaviour.-Academic Press, New York.
- - (1998). Social conflict. - In: Handbook of social psychology (Gilbert, D.T., Fiske, S.T. & Lindzey, G., eds), McGraw Hill, Boston.
-- & Rubin, J.Z. (1986). Social conflict: escalation, stalemate, and settlement.-Random House, New York.
- - & Carnevale, P.J. (1993). Negotiation in social conflict. - Brooks/Cole Pub. Co., Pacific Grove, California.
Ratcliffe, D.A. (1980). The peregrine falcon.- Buteo Books, Vermillion, South Dakota.
Reese, E.S. (1975). A comparative field study of the social behaviour and related ecology of reef fishes of the family Chaetodontidae.- Z. Tierpsych. 37, p. 37–61.
Rubin, J.Z., Pruitt, D.G. & Kim, S.H. (1994). Social conflict: escalation, stalemate, and settlement.- McGraw Hill, New York.
Schlupp, I., McKnab, R. & Ryan, M.J. (2001). Sexual harassment as a cost for molly females: bigger males cost less.- Behaviour 138, p. 277–286.
Scott, P.M. (1972). The swans.- Joseph, London
Seeley, T.D. & Buhrman, S.C. (2001). Nest-site selection in honey bees: how well do swarms implement the ‘best-of-N’ decision rule?-Behav. Ecol. Sociobiol. 49, p. 416–427.
Sigg, J. & Stolba, A. (1981). Home range and daily march in a hamadryas baboon troup.- Folia Primatol. 36, p. 40–75.
Sokal, R.R. & Rohlf, F.J. (1995). Biometry: the principles and practice of statistics in biological research.-W.H. Freeman, New York.
Stamps, J.A. (1994). Territorial behaviour: testing the assumptions.-Adv. Stud. Behav. 23, p. 173–232.
--& Krishnan, V.V. (1998). Territory acquisition in lizards. IV. Obtaining high status and exclusive home ranges.-Anim. Behav. 54, p. 461–472.
- - & - -(1999). A learning-based model of territory establishment. - Quart. Rev. Biol. 74, p. 291–318.
- - & - -(2001). How territorial animals compete for divisible space: a learning-based model with unequal competitors.-Am. Nat. 157, p. 154–169.
Tarof, S.A. & Ratcliffe, L.M. (2000). Pair formation and copulation behaviour in least flycatcher clusters.- Condor 102, p. 832–837.
Tinbergen, N. (1953). The herring gull's world; a study of the social behaviour of birds. - Collins, London.
Visscher, P.K. & Camazine, S. (1999). Collective decisions and cognition in bees.- Nature 97, p. 400.
Wachtmeister, C.A. (2001). Display in monogamous pairs: a review of empirical data and evolutionary explanations.- Anim. Behav. 61, p. 861–868.
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Goglia, F., Silvestri, E. & Lanni, A. Thyroid Hormones and Mitochondria. Biosci Rep 22, 17–32 (2002). https://doi.org/10.1023/A:1016056905347
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DOI: https://doi.org/10.1023/A:1016056905347