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Quantitative Determination of Crystallinity of α-Lactose Monohydrate by DSC

Journal of Thermal Analysis and Calorimetry volume 68, pages 503–510 (2002)Cite this article

Abstract

In pharmaceutical practice it is important and useful to know the crystallinity of materials and to monitor it during formulation development, production processes and storage. The purpose of this study was to assess the quantitative capability of DSC for determining crystallinity in crystalline/amorphous powder mixtures and to compare the accuracy of the DSC method with that of conventional powder X-ray diffraction. Alpha-lactose monohydrate was chosen as the model material. On the basis of this study it can be concluded, that DSC method can be applied safely for semiquantitative evaluation of the crystallinity of lactose samples consisting of an amorphous content higher than 20%.

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References

  1. P. York, Int. J. Pharm., 14 (1983) 1.

    Article  CAS  Google Scholar 

  2. A. Saleki-Gerhardt, Int J. Pharm., 101 (1994) 237.

    Article  CAS  Google Scholar 

  3. B. C. Hancock and G. Zografi, J. Pharm. Sci., 86 (1997) 1.

    Article  CAS  Google Scholar 

  4. D. H. Doff, Analyst, 111 (1986) 179.

    Article  CAS  Google Scholar 

  5. V. P. Tanninen, Int. J. Pharm., 81 (1992) 169.

    Article  CAS  Google Scholar 

  6. D. M. Price, M. Reading, A. Hammiche and M. Pollock, J. Therm. Anal. Cal., 60 (2000) 723.

    Article  CAS  Google Scholar 

  7. P. Young, D. Dollimore and C. A. Schall, J. Therm. Anal. Cal., 62 (2000) 163.

    Article  CAS  Google Scholar 

  8. A. C. D. de Madeiros, N. A. B. de Cervantes, A. P. B. Gomes Barreto and R. O. Mačedo, J. Therm. Anal. Cal., 64 (2001) 745.

    Article  Google Scholar 

  9. D. Giron, J. Therm. Anal. Cal., 64 (2001) 37.

    Article  CAS  Google Scholar 

  10. S. D. Clas and B. C. Hancock, Int J. Pharm., 121 (1995) 73.

    Article  CAS  Google Scholar 

  11. M. Angberg, Thermochim. Acta, 248 (1995) 161.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University of Szeged, H-6720, Szeged, Eötvös u. 6, Hungary

    Á. GombÁs, P. Szabó-Révész, M. Kata, G. Regdon Jr. & I. Erős

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  1. Á. GombÁs
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  2. P. Szabó-Révész
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  3. M. Kata
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  4. G. Regdon Jr.
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  5. I. Erős
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GombÁs, Á., Szabó-Révész, P., Kata, M. et al. Quantitative Determination of Crystallinity of α-Lactose Monohydrate by DSC. Journal of Thermal Analysis and Calorimetry 68, 503–510 (2002). https://doi.org/10.1023/A:1016039819247

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  • DOI: https://doi.org/10.1023/A:1016039819247

  • crystallinity
  • DSC
  • lactose
  • X-ray powder diffraction