Skip to main content
SpringerLink
Log in

Thermal and FTIR Characterization of Films Obtained From Carbopol/Surfactant Aqueous Solutions

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

The suitability of differential scanning calorimetry (DSC) as a routine technique to characterize polymer/surfactant interactions in aqueous medium was evaluated in films obtained by evaporation of binary aqueous mixtures of Carbopol® 934, a cross-linked poly(acrylic acid), and Tween 80, Pluronic F-127 (non-ionic surfactants), sodium dodecylsulphate (SDS, anionic surfactant), or benzalkonium chloride (cationic surfactant). In all cases, the interactions that occur at specific proportions of both components, as shown in the FTIR spectra, could be detected by shifts of some melting peaks. Lorentzian deconvolution of carbopol carbonyl groups (1690–1730 cm−1) was used to quantify the intensity of the interaction between the polymer and the non-ionic surfactants. DSC curves revealed the compatibility of carbopol with Tween 80 or SDS, and its strong affinity for Pluronic F-127 or benzalkonium chloride. This surfactant binds electrostatically to carbopol causing the formation of an insoluble polyelectrolyte complex, the composition and thermal behavior of which are very different from those of the films obtained from the supernatant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. P. Hansson and B. Lindman, Curr. Opin. Colloid Interface Sci., 1 (1996) 604.

    Article  CAS  Google Scholar 

  2. R. Barreiro-Iglesias, C. Alvarez-Lorenzo and A. Concheiro, J. Control. Release, 77 (2001) 59.

    Article  CAS  Google Scholar 

  3. R. Duro, C. Alvarez-Lorenzo, C. Souto, J. L. Gómez-Amoza, R. Martínez-Pacheco and A. Concheiro, Chem. Pharm. Bull., 46 (1998)1421.

    CAS  Google Scholar 

  4. P. S. Leung and E. D. Goddard, Langmuir, 7 (1991) 608.

    Article  CAS  Google Scholar 

  5. U. Kästner, H. Hoffmann, R. Donges and R. Ehrler, Colloids Surf., 112 (1996) 209.

    Article  Google Scholar 

  6. O. E. Philippova, L. A. Chtcheglova, N. S. Karybiants and A. R. Khokhlov, Polym. Gel Networks, 6 (1998) 409.

    Article  CAS  Google Scholar 

  7. M. Goldraich, J. R. Schwart, J. L. Burns and Y. Talmon, Colloids Surf. A, 125 (1997) 2131.

    Article  Google Scholar 

  8. P. Mura, M. T. Faucci, A. Manderioli, G. Bramanti and P. Parrini, Drug Dev. Ind. Pharm., 25 (1999) 257.

    Article  CAS  Google Scholar 

  9. L. A. Kanis, F. C. Viel, J. S. Crespo, J. R. Bertolino, A. T. N. Pires and V. Soldi, Polymer, 41 (2000) 3303.

    Article  Google Scholar 

  10. T. Ozeki, H. Yuasa and Y. Kanaya, J. Control. Release, 63 (2000) 287.

    Article  CAS  Google Scholar 

  11. D. F. Anghel, S. Saito, A. Iovescu and A. Baran, Colloids Surf. A, 90 (1994) 89.

    Article  CAS  Google Scholar 

  12. I. D. Robb and P. Stevenson, Langmuir, 16 (2000) 7168.

    Article  CAS  Google Scholar 

  13. J. L. Ford and P. Timmins, Pharmaceutical Thermal Analysis, Ellis Horwood Limited, Chichester 1989, p. 238.

    Google Scholar 

  14. B. Pérez-Marcos, R. Martínez-Pacheco, J. L. Gómez-Amoza, C. Souto, A. Concheiro and R. C. Rowe, Int. J. Pharm., 100 (1993) 207.

    Article  Google Scholar 

  15. J. Dong, Y. Ozaki and K. Nakashima, Macromolecules, 30 (1997) 1111.

    Article  CAS  Google Scholar 

  16. E. Sjökvist, C. Nyström and M. Aldén, Int. J. Pharm., 69 (1991) 53.

    Article  Google Scholar 

  17. D. Ostrovskii, A. L. Kjoniksen, B. Nystrom and L. M. Torell, Macromolecules, 32 (1999) 1534.

    Article  CAS  Google Scholar 

  18. E. A. Bekturov and L. A. Bimendina, Adv. Polym. Sci., 41 (1981) 99.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain

    R. Barreiro-Iglesias, C. Alvarez-Lorenzo & A. Concheiro

Authors
  1. R. Barreiro-Iglesias
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Alvarez-Lorenzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Concheiro
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Concheiro.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barreiro-Iglesias, R., Alvarez-Lorenzo, C. & Concheiro, A. Thermal and FTIR Characterization of Films Obtained From Carbopol/Surfactant Aqueous Solutions. Journal of Thermal Analysis and Calorimetry 68, 479–488 (2002). https://doi.org/10.1023/A:1016035618338

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016035618338

Search

Navigation