This is a preview of subscription content, log in via an institution to check access.
REFERENCES
J. P. Bai, and G. L. Amidon. Structural specificity of mucosal-cell transport and metabolism of peptide drugs: implication for oral peptide drug delivery. Pharm. Res. 9:969–78 (1992).
A. Yamamoto, E. Hayakawa, and V. H. L. Lee. Insulin and proinsulin proteolysis in mucosal homogenates of the albino rabbit: Implications in peptide delivery from nonoral routes. Life Sci. 47:2465–2474 (1990).
J. P. F. Bai. Colonic delivery of peptide and protein drugs—consideration of intracellular proteolytic enzymes. S.t.p. Pharma Sciences 5:30–35 (1995).
J. P. F. Bai, and L. L. Chang. Transepithelial transport of insulin: I. Insulin degradation by insulin-degrading enzyme in small intestinal epithelium. Pharm. Res. 12:1171–1175 (1995).
W. C. Duckworth. Insulin degradation: Mechanisms, products, and significance. Endocrine Rev. 9:319–345 (1988).
W. C. Duckworth. Insulin and glucagon binding and degradation by kidney cell membranes. Endocrinol. 102:1766–74 (1978).
W. C. Duckworth. Insulin degradation by liver cell membranes. Endocrinol. 104:1758–64 (1979).
I. D. Goldfine, J. A. Williams, A. C. Bailey, K. Y. Wong, Y. Iwamoto, K. Yokono, S. Baba, and R. A. Roth. Degradation of insulin by isolated mouse pancreatic acini. Evidence for cell surface protease activity. Diabetes 33:64–72 (1984).
K. Yokono, R. A. Roth, and S. Baba. Identification of insulin-degrading enzyme on the surface of cultured human lymphocytes, rat hepatoma cells, and primary cultures of rat hepatocytes. Endocrinol. 111:1102–8 (1982).
M. Bendayan, E. Ziv, S. R. Ben, O. H. Bar, and M. Kidron. Morpho-cytochemical and biochemical evidence for insulin absorption by the rat ileal epithelium. Diabetologia 33:197–204 (1990).
M. Bendayan, E. Ziv, D. Gingras, S. R. Ben, O. H. Bar, and M. Kidron. Biochemical and morpho-cytochemical evidence for the intestinal absorption of insulin in control and diabetic rats. Comparison between the effectiveness of duodenal and colon mucosa. Diabetologia 37:119–26 (1994).
K. Shii, and R. A. Roth. Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease. Proc. Natl. Acad. Sci. USA 83:4147–51 (1986).
J. P. Bai, and L. L. Chang. Comparison of site-dependent degradation of peptide drugs within the gut of rats and rabbits. J. Pharm. Pharmacol. 45:1085–7 (1993).
M. D. Fernandez-Moreno, M. Serrano-Rios, and J. C. Prieto. Identification of insulin receptors in epithelial cells from duodenum, jejunum, ileum, caecum, colon, and rectum in the rat. Diabete Metab. 13:135–139 (1987).
J. A. Atchison, W. E. Grizzle, and D. J. Pillion. Colonic absorption of insulin: An in vitro and in vivo evaluation. J. Pharmacol. Exp. Ther. 248:567–572 (1989).
Rights and permissions
About this article
Cite this article
Chang, LL., Bai, J.P.F. Evidence for the Existence of Insulin-Degrading Enzyme on the Brush-Border Membranes of Rat Enterocytes. Pharm Res 13, 801–803 (1996). https://doi.org/10.1023/A:1016024322209
Issue Date:
DOI: https://doi.org/10.1023/A:1016024322209