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Thermal Properties of Binary Mixtures of β-Cyclodextrin with Carbamazepine Polymorphs

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Abstract

The thermal behaviour of binary mixtures between β-cyclodextrin (β-CD) and either carbamazepine polymorphic Form I (CBZ I), Form III (CBZ III) or dihydrate was investigated in order to assess possible interactions of CBZ solid phases with β-CD. Physical mixtures and kneaded binaries of β-CD and different CBZ crystal forms were studied by differential scanning calorimetry, thermogravimetric analysis and hot stage microscopy. The pattern of transition of CBZ Form III into Form I is strongly influenced by β-CD. The liquid-solid transition is practically absent when anhydrous CBZ/β-CD mixes are tested, as a consequence of an interaction between β-CD and liquid CBZ that hinders CBZ recrystallisation as Form I occurring after CBZ Form III melting.

Water loss on heating of CBZ dihydrate in the presence of β-CD leads in all cases to the formation of CBZ Form I.

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Authors and Affiliations

  1. Department of Pharmacy, University of Parma, Parco Area delle Scienze 27/A, 43100, Parma, Italy

    A. Cvetkovskii, R. Bettini, I. Casini, A. Rossi & F. Giordano

  2. Department for Pharmaceutical Technology, Faculty of Pharmacy, Belgrade University, V. Stepe 450, 11221, Belgrade, Yugoslavia

    A. Cvetkovskii, Lj. Tasic & M. Stupar

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  1. A. Cvetkovskii
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  2. R. Bettini
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  3. Lj. Tasic
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  4. M. Stupar
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  5. I. Casini
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  6. A. Rossi
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  7. F. Giordano
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Correspondence to R. Bettini.

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Cvetkovskii, A., Bettini, R., Tasic, L. et al. Thermal Properties of Binary Mixtures of β-Cyclodextrin with Carbamazepine Polymorphs. Journal of Thermal Analysis and Calorimetry 68, 669–678 (2002). https://doi.org/10.1023/A:1016020709678

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