Abstract
The effect of cyclodextrin complexation of sulphamethizole (SM) was studied. Two systems were prepared with two cyclodextrin derivatives, β-cyclodextrin (BCD) and hydroxypropyl-β-cyclodextrin (HPBCD): binary complexes and multicomponent systems (cyclodextrins and a hydroxylpropylmethyl cellulose K4M). Inclusion complexes were prepared by freeze-drying and characterized by thermal analysis (DSC) and X-ray diffractometry. The presence of the polymer in the solution increases the effect of cyclodextrins – specially BCD – on the solubility of SM. In solid state, binary inclusion complexes enhance the dissolution behaviour of SM but, from the multi-component complexes, the polymer controls the release of the drug.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
T. Loftsson and M. Brewster, J. Pharm. Sci., 85 (1996) 1017.
T. Irie and K. Uekama, J. Pharm. Sci., 86 (1997) 147.
B. Cappello, C. Carmignani, M. Iervolino, M. Immacolata La Rotonda and M. Fabrizio Saettone, Int. J. Pharm., 213 (2001) 75.
T. Loftsson, M. Másson and J. F. Sigurjónsdóttir, S T P Pharma Sci., 9 (1999) 237.
G. Ganzerli, L. van Santvliet, E. Verschuren and A. Ludwig, Pharmazie, 51 (1996) 357.
T. Hladoń and B. Cwiertnia, Pharmazie, 49 (1994) 497.
M. Másson and T. Loftsson, Polysaccharide applications. Cosmetics and Pharmaceutics, American Chemical Society, Washington 1999, p. 24.
A. M. Sigurdardóttir and T. Loftsson, Int. J. Pharm., 126 (1995) 73.
T. Loftsson, T. K. Gudmundsdóttir and H. Fridriksdóttir, Drug Dev. Ind. Pharm., 22 (1996) 401.
J. Savolainen, K. Järvinen, H. Taipale, P. Jarho, T. Loftsson and T. Järvinen, Pharm. Res., 15 (1998) 1696.
M. T. Esclusa-Díaz, M. Gayo-Otero, M. B. Pérez-Marcos, J. L. Vila-Jato and J. J. Torres-Labandeira, Int. J. Pharm., 142 (1996) 183.
A. Gerloczy, J. Szeman, K. Csabai, I. Kolbe, L. Jicsinszky, D. Acerbi, P. Ventura, E. Redenti and J. Szejtli, Proc. of the 8th International Symposium on Cyclodextrins, Kluwer Academic Publishers, Dordrecht 1996, p. 515.
B. Pose-Vilarnovo, I. Perdomo-López, M. Echezarreta-López, P. Schroth-Pardo, E. Estrada and J. J. Torres-Labandeira, Eur. J. Pharm. Sci., 13 (2000) 325.
T. Higuchi and K. A. Connors, Adv. Anal. Chem. Instr., 4 (1965) 117.
T. Loftsson, H. Fridriksdàttir, S. Thórisdóttir and E. Stefánsson, Int. J. Pharm., 104 (1994) 181.
K. A. Khan, J. Pharm. Pharmacol., 27 (1975) 48.
F. Veiga, Program and Abstracts of the 9th International Symposium on Cyclodextrins, 1999, p. 3-P–3.
M. Kurozumi, N. Nambu and T. Nagai, Chem. Pharm. Bull., 23 (1975) 3062.
T. Loftsson, Pharmazie, 53 (1998) 733.
E. M. Sammy and S. M. Safwat, STP Pharma Sci., 4 (1994) 458.
M. J. Vázquez, B. Pérez-Marcos, J. L. Gómez-Amoza, R. Martínez-Pacheco, C. Souto and A. Concheiro, Drug Dev. Ind. Pharm., 18 (1992) 1355.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pose-Vilarnovo, B., Rodríguez-Tenreiro Sánchez, X., Pérez-Marcos, M.B. et al. Sulphamethizole-Cyclodextrin-Hydroxy Propylmethyl Cellulose Multicomponent Complexes. Journal of Thermal Analysis and Calorimetry 68, 657–667 (2002). https://doi.org/10.1023/A:1016016525607
Issue Date:
DOI: https://doi.org/10.1023/A:1016016525607