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Structure and Function of G Protein Coupled Receptors

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Abstract

The G protein coupled receptors (GPC-Rs) comprise a large superfamily of genes encoding numerous receptors which all show common structural features, e.g., seven putative membrane spanning domains. Their biological functions are extremely diverse, ranging from vision and olfaction to neuronal and endocrine signaling. The GPC-Rs couple via multiple G proteins to a growing number of recognized second messenger pathway, e.g., cAMP and phosphatidyl inositol turnover. This review summarizes our current knowledge of the molecular mechanisms by which the GPC-Rs activate second messenger systems, and it addresses their regulation and structure.

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Authors and Affiliations

  1. School of Pharmacy, University of California, San Francisco, California, 94143

    Jelveh Lameh, Ric I. Cone & Wolfgang Sadée

  2. Department of Pharmacology, Faculty of Dentistry, Osaka University, Osaka, 565, Japan

    Sadaaki Maeda

  3. Neurex Corporation, 3760 Haven Avenue, Menlo Park, California, 94025

    Mohan Philip, Maithe Corbani, László Nádasdi & J. Ramachandran

  4. Merck Sharp & Dohme Research Laboratories, Westpoint, Pennsylvania, 19486

    Graham M. Smith

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  1. Jelveh Lameh
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Lameh, J., Cone, R.I., Maeda, S. et al. Structure and Function of G Protein Coupled Receptors. Pharm Res 7, 1213–1221 (1990). https://doi.org/10.1023/A:1015969301407

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