Pharmaceutical Research

, Volume 6, Issue 9, pp 743–747

Ion Pair Transport Across Membranes

  • Reinhard Neubert


The present review discusses drugs and counter ions suitable for ion pair transport (IPT). Ion pairing is shown to effectively increase the lipophilicity and transport rate of polar drugs across lipid membranes. The proposed mechanisms of IPT are discussed in detail. A marked change in drug properties upon ion pair formation is necessary to improve the bioavailability of hydrophilic ionizable drugs.

ion pair transport (IPT) mechanism of IPT hydrophilic drugs counter ions effects on pharmacokinetics 


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  1. 1.
    B. C. Lippold. Pharmazie 28:713–721 (1973).Google Scholar
  2. 2.
    J. H. G. Jonkman and C. A. Hunt. Pharm. Weekblad Sci. 5:41–48 (1983).Google Scholar
  3. 3.
    F. M. Plakogiannis, E. J. Lien, C. Harris, and J. A. Biles. J. Pharm. Sci. 59:197–200 (1970).Google Scholar
  4. 4.
    J. H. G. Jonkman. Pharm. Weekblad Sci. 1:291–294 (1979).Google Scholar
  5. 5.
    R. Neubert, W. Fürst, H. Schleiermacher, P. Bergmann, and E. Stolte. Pharmazie 42:309–311 (1987).Google Scholar
  6. 6.
    R. Neubert, W. Fürst, P. Schulze, H.-J. Loh, M. Jirka, and U. Wenzel. Pharmazie 42:393–394 (1987).Google Scholar
  7. 7.
    R. Neubert, G. Albrecht, C. Taube, M. Weiss, and W. Fürst. Pharmazie 43:632–633 (1988).Google Scholar
  8. 8.
    R. Neubert, A. Ritter, G. A. Albrecht, H.-J. Loh, M. Jirka, and W. Fürst. Pharmazie 43:848–849 (1988).Google Scholar
  9. 9.
    M. Gallerate, M. R. Gasco, and M. Trotta. Acta Pharm. Technol. 34:102–105 (1988).Google Scholar
  10. 10.
    P. G. Green and J. Hadgraft. Int. J. Pharm. 37:251–255 (1987).Google Scholar
  11. 11.
    J. Hadgraft, P. K. Wotton, and K. A. Walters. J. Pharm. Pharmacol. 37:725–727 (1985).Google Scholar
  12. 12.
    B. C. Lippold and W. A. Lettenbauer. Pharmazie 33:221–225 (1978).Google Scholar
  13. 13.
    B. C. Lippold and G. F. Schneider. Pharmazie 31:237–239 (1976).Google Scholar
  14. 14.
    R. Neubert, W. Böhm, S. Dabow, and W. Fürst. Pharmazie 39:401–403 (1984).Google Scholar
  15. 15.
    M. Trotta, M. R. Gasco, and M. E. Carlotti. Pharm. Acta Helv. 63:23–25 (1988).Google Scholar
  16. 16.
    P. Langguth and E. Mutschler. Arzneim.-Forsch. 37:1362–1366 (1987).Google Scholar
  17. 17.
    H. Stricker. Pharm. Ind. 33:499–500 (1971).Google Scholar
  18. 18.
    T. H. Wilson and G. Wiseman. J. Physiol. 123:116–125 (1954).Google Scholar
  19. 19.
    M. R. Gasco, M. Trotta, and M. Eandi. J. Pharm. Biomed. Anal. 2:425–428 (1984).Google Scholar
  20. 20.
    T. Mothes, R. Neubert, and W. Fürst. Pharmazie 38:47–47 (1983).Google Scholar
  21. 21.
    S. J. Lee, T. Kurihara-Bergström, and S. W. Kim. Int. J. Pharm. 47:59–73 (1987).Google Scholar
  22. 22.
    R. Neubert and T. Dittrich. Pharmazie 44:67–68 (1989).Google Scholar
  23. 23.
    Ch. S. Young, Ch.-K. Shi, M.-H. Lee, and Sh.-K. Kim. Int. J. Pharm. 45:59–64 (1988).Google Scholar
  24. 24.
    J. Hadgraft, K. A. Walters, and P. K. Wotton. Int. J. Pharm. 32:257–263 (1986).Google Scholar
  25. 25.
    J. Hadgraft and P. Wotton. J. Pharm. Pharmacol. 36:22P (1984).Google Scholar
  26. 26.
    N. Schurgers, C. J. De Blaey, and E. Tomkinson. J. Pharm. Pharmacol. 36:45 (1984).Google Scholar
  27. 27.
    C. G. Wilson, E. Tomkinson, S. S. Davis, and O. Olejnik. J. Pharm. Pharmacol. 31:749–753 (1981).Google Scholar
  28. 28.
    M. Ahmed, J. Hadgraft, and I. W. Kellaway. Int. J. Pharm. 12:219–229 (1982).Google Scholar
  29. 29.
    M. Boronjerdi. Drug. Dev. Ind. Pharm. 13:181–190 (1987).Google Scholar
  30. 30.
    R. Neubert, W. Fürst, and H. Schleiermacher. Pharmazie 40:426–427 (1985).Google Scholar
  31. 31.
    R. Neubert, W. Fürst, and H. Schleiermacher. Pharmazie 40:497 (1985).Google Scholar
  32. 32.
    W. C. Babock, R. W. Baker, and E. D. Lachapell. J. Membrane Sci. 7:71–76 (1980).Google Scholar
  33. 33.
    E. L. Cussler and D. F. Evans. J. Membrane Sci. 6:113–119 (1980).Google Scholar
  34. 34.
    W. Molnar, C.-P. Wang, and P. F. Evans. J. Membrane Sci. 4:129–137 (1978).Google Scholar
  35. 35.
    W. J. Albery, J. F. Burke, E. B. Leffler, and J. Hadgraft. J. C. S. Faraday Trans. 72:1618–1626 (1976).Google Scholar
  36. 36.
    N. Barker and J. Hadgraft. Int. J. Pharm. 8:193–202 (1981).Google Scholar
  37. 37.
    BP Patent 154 877.Google Scholar
  38. 38.
    R. Neubert, W. Fürst, S. Schneider, H. Müller, H. J. Loh, and M. Jirka. Pharmazie 42:29–30 (1987).Google Scholar
  39. 39.
    Ch.-K. Shim. Arch. Pharm. Res. 9:49–54 (1986).Google Scholar
  40. 40.
    R. Neubert, A. Härtl, C. Hause, and R. Amlacher. Pharmazie (in press).Google Scholar
  41. 41.
    S. S. Davis, J. F. M. Kinkel, O. Olenik, and E. Tomlinson. J. Pharm. Pharmacol. 33:104P (1981).Google Scholar

Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • Reinhard Neubert
    • 1
  1. 1.Sektion Pharmazie derMartin-Luther-UniversitätHalle/Saale

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