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Evaluation of Polyvinyl Alcohol Hydrogel as a Sustained-Release Vehicle for Rectal Administration of Indomethacin

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Abstract

In order to evaluate an indomethacin poly vinyl alcohol (PVA) hydrogel for rectal administration, the in vitro release characteristics of indomethacin from the hydrogel and indomethacin plasma concentrations after rectal administration were examined. The PVA hydrogel containing indomethacin was prepared by a low-temperature crystallization method. The release of indomethacin from the PVA hydrogel agreed with the Fickian diffusion model for 10 hr. Rectal administration of indomethacin hydrogels to rats yielded high indomethacin plasma concentrations, without producing a sharp peak, and a sustained-release effect. In dogs, the indomethacin hydrogel produced a similar sustained-release effect; however, the indomethacin plasma concentration was relatively low compared with that of an indomethacin suppository.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 2-10-65 Kawai, Matsubara-city, Osaka, 580, Japan

    Kazuhiro Morimoto, Atsushi Nagayasu, Shinichi Fukanoki & Katsuaki Morisaka

  2. Research Center for Medical Polymers and Biomaterials, Kyoto University, 53 Kawahara-cho, Sakyo-ku, Kyoto, 606, Japan

    Suong-Hyu Hyon & Yoshito Ikada

Authors
  1. Kazuhiro Morimoto
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  2. Atsushi Nagayasu
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  3. Shinichi Fukanoki
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  4. Katsuaki Morisaka
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  5. Suong-Hyu Hyon
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  6. Yoshito Ikada
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Morimoto, K., Nagayasu, A., Fukanoki, S. et al. Evaluation of Polyvinyl Alcohol Hydrogel as a Sustained-Release Vehicle for Rectal Administration of Indomethacin. Pharm Res 6, 338–341 (1989). https://doi.org/10.1023/A:1015958710435

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  • DOI: https://doi.org/10.1023/A:1015958710435

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