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Antihypertensive Activity of 2[(2-Hydroxyphenyl) amino] -4(3H)-quinazolinone

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Abstract

Two 2-substituted 4(3H)-quinazolinones were synthesized through an easy one-step synthetic procedure. One of them (1), which was synthesized by the reaction of l-(2-hydroxyphenyl)-2-thiourea and isatoic anhydride, contained a guanidino moiety and showed antihypertensive activity following cumulative intravenous administration to anesthetized spontaneously hypertensive rats. The other compound (2) does not contain the guanidino group and did not exhibit antihypertensive activity.

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Authors and Affiliations

  1. Medical Products Department, Division of Pharmaceuticals R&D, Experimental Station, E. I. du Pont de Nemours & Company, Inc, Wilmington, Delaware, 19898

    Munir A. Hussain & Eli Shefter

  2. Medical Products Department, Division of Cardiovascular Sciences, Experimental Station, E. I. du Pont de Nemours & Company, Inc, Wilmington, Delaware, 19898

    Andrew T. Chiu, William A. Price & Pieter B. Timmermans

Authors
  1. Munir A. Hussain
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  2. Andrew T. Chiu
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  3. William A. Price
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  4. Pieter B. Timmermans
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  5. Eli Shefter
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Hussain, M.A., Chiu, A.T., Price, W.A. et al. Antihypertensive Activity of 2[(2-Hydroxyphenyl) amino] -4(3H)-quinazolinone. Pharm Res 5, 242–244 (1988). https://doi.org/10.1023/A:1015949931218

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  • DOI: https://doi.org/10.1023/A:1015949931218

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