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Antimuscarinic Effects of (R)- and (S)-Oxyphencyclimine Hydrochloride

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Abstract

The (R)-( + )- and (S)-( – )-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-( – )- and (S)-( + )-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-( + )-enantiomer inhibited binding 29 times more potently than the (S)-( – )-enantiomer.

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Authors and Affiliations

  1. Department of Chemistry, The Agricultural University of Norway, Box 30, N 1432 Ås-NLH, Norway

    Lise Schjelderup & Arne J. Aasen

  2. Bristol-Myers Company, Wallingford, Connecticut, 06492

    Michael R. Kozlowski

  3. Pfizer Central Research, Groton, Connecticut, 06340

    Albert Weissman

Authors
  1. Lise Schjelderup
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  2. Michael R. Kozlowski
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  3. Albert Weissman
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  4. Arne J. Aasen
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Schjelderup, L., Kozlowski, M.R., Weissman, A. et al. Antimuscarinic Effects of (R)- and (S)-Oxyphencyclimine Hydrochloride. Pharm Res 5, 236–237 (1988). https://doi.org/10.1023/A:1015945830309

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  • DOI: https://doi.org/10.1023/A:1015945830309

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