Skip to main content
SpringerLink
Log in

Tumor necrosis factor-α gene promoter polymorphism in coal worker' pneumoconiosis

Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Cite this article

Abstract

Tumor necrosis factor-alpha (TNF-α) is believed to play a central role in the pathogenesis of pneumoconiosis. TNF2, a polymorphism in the TNF-α gene promoter, has been associated with an increase in TNF-α production and airway inflammation. To investigate the frequency of TNF2 in patients who have coal workers' pneumoconiosis (CWP) and to determine whether it is associated with development of a large opacity in CWP, we investigated the expression of the TNF2 allele in 80 patients who had CWP and in 54 healthy controls using restriction fragment length polymorphism (RFLP). Compared to controls (10.2%), the frequency of the TNF2 allele was greater in the CWP patients (20.6%). Furthermore, the TNF2 allele was very common in patients who had a large opacity (28.2%) in comparison with 13.4% in those with simple CWP. From these data, we suggest that the TNF2 allele is associated with the development of a large opacity in CWP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Borm PJ, Palmen N, Engelen JJ, Buurman WA: Spontaneous and stimulated release of tumor necrosis factor-α (TNF) from blood monocytes of miners with coal workers' pneumoconiosis. Am Rev Respir Dis 138: 1589–1594, 1988

    PubMed  Google Scholar 

  2. Lassalle P, Gosset P, Aerts C, Fournier E, Lafitte JJ, Degreef JM, Wallaert B, Tonnel AB, Voisin C: Abnormal secretion of interleukin-1 and tumor necrosis factor-α by alveolar macrophages in coal workers' pneumoconiosis: Comparison between simple pneumoconiosis and progressive massive fibrosis. Exp Lung Res 16: 73–80, 1990

    PubMed  Google Scholar 

  3. Schins RP, Borm PJ: Epidemiological evaluation release of monocyte TNF-α as an exposure and effect marker in pneumoconiosis: A five year follow up study among coal workers. Occup Environ Med 52: 441–450, 1995

    PubMed  Google Scholar 

  4. Driscoll KE: TNF alpha and MIP-2: Role in particle-induced inflammation and regulation by oxidative stress. Toxicol Lett 112- 113: 177–183, 2000

    Article  PubMed  Google Scholar 

  5. Rink L, Kirchner H: Recent progress in the tumor necrosis factor-α field. Int Arch Aller Immunol 111: 199–209, 1996

    Google Scholar 

  6. Probert L, Selmaj K: TNF and related molecules: Trends in neuroscience and clinical applications. J Neuroimmunol 72: 113–117, 1997

    PubMed  Google Scholar 

  7. Czaja AJ, Cookson S, Contantini PK, Clare M, Underhill JA, Donaldson PT: Cytokine polymorphisms associated with clinical features and treatment outcome in type 1 autoimmune hepatitis. Gastroenterology 117: 728–731, 1999

    PubMed  Google Scholar 

  8. Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB, Duff GW: An allelic polymorphism within the human tumor necrosis factor-α promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med 177: 557–560, 1993

    PubMed  Google Scholar 

  9. Wilson AG, Symons JA, McDowell TL, McDewitt HO, Duff GW: Effects of a polymorphism in the human tumor necrosis factor αpromoter on transcriptional activation. Proc Natl Acad Sci USA 94: 3195–3199, 1997

    Article  PubMed  Google Scholar 

  10. Kroeger KM, Carville KS, Abraham LJ: The - tumor necrosis factor-α promoter polymorphism effects transcription. Mol Immunol 34: 391–399, 1997

    PubMed  Google Scholar 

  11. McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D: Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria. Nature 371: 508–510, 1994

    Article  PubMed  Google Scholar 

  12. Mira JP, Cariou A, Crall F, Declaux C, Losser MR, Hechmati F, Cheval C, Monchi M, Teboul JL, Riche F, Leleu G, Arbibe L, Mignon A, Delpech M, Dhainaut JF: Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality: A multicancer study. JAMA 282: 561–568, 1999

    PubMed  Google Scholar 

  13. Huang SL, Su CH, Chang SC: Tumor necrosis factor-alpha gene polymorphism in chronic bronchitis. Am J Respir Crit Care Med 156: 1436–1439, 1997

    PubMed  Google Scholar 

  14. Li Kam Wa TC, Mansur AH, Britton J, Williams G, Pavord I, Richards K, Campbell DA, Morton N, Holgate ST, Morrison JF: Association between- 308 tumor necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma. Clin Exp Aller 29: 1204–1208, 1999

    Google Scholar 

  15. Zhai R, Jetten M, Schins RP, Franssen H, Borm PJ: Polymorphism in the promoter of the tumor necrosis factor-alpha gene in coal miners. Am J Ind Med 34: 318–324, 1998

    PubMed  Google Scholar 

  16. Yucesoy B, Vallyathan V, Landsittel DP, Sharp DS, Weston A, Burleson GR, Simeonova P, McKinstry M, Luster MI: Association of tumor necrosis factor-and interleukin-1 gene polymorphisms with silicosis. Toxicol Appl Pharmacol 172: 75–82, 2001

    PubMed  Google Scholar 

  17. Parker JE, Banks DE: Lung disease in coal workers. In: D.E. Banks, J.E. Parker (eds). Occupational Lung Disease. An International Perspective. Chapman and Hall, London, 1998, pp 161–181

    Google Scholar 

  18. International Labour Office: Guidelines for the Use of ILO International Classification of Radiographs of Pneumoconioses. Revised Edition 1980, International Labour Office, Geneva, 1980, pp 1–20

    Google Scholar 

  19. Kim KA, Lim Y, Kim JH, Kim EK, Chang HS, Park YM, Ahn BY: Potential biomarker of coal workers' pneumoconiosis. Toxicol Lett 108: 297–302, 1999

    PubMed  Google Scholar 

  20. Mycko M, Kowalski W, Kwinkowski M, Buenafe AC, Szymanska B, Tronczynska E, Plucienniczak A, Selmaj K: Multiple sclerosis: The frequency of allelic forms of tumor necrosis factor and lymphotoxin alpha. J Neuroimmunol 84: 198–206, 1998

    PubMed  Google Scholar 

  21. Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA, McDevitt HO: Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor-α: Relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci USA 87: 1233–1237, 1990

    PubMed  Google Scholar 

  22. Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M, Thomsen M, Nerup J, Cambon-Tompsen A: Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: A possible link to insulin-dependent diabetes mellitus. Eur J Immunol 23: 224–231, 1993

    PubMed  Google Scholar 

  23. Kroeger KM, Abraham LJ: Identification of an AP-2 element in the - 323 to - 285 region of the TNF-alpha gene. Biochem Mol Biol Int 40: 43–51, 1996

    PubMed  Google Scholar 

  24. Messer G, Kick G, Ranki A, Koskimies S, Reunala T, Meurer M: Polymorphism of the tumor necrosis genes in patients with dermatitis herpetiformis. Dermatology 189(suppl 1): 135–137, 1994

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Occupational and Environmental Medicine, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea

    Kyoung Ah Kim & Young Lim

  2. Department of General Toxicology, Korea Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea

    Yong-Yeun Cho, Jung Sik Cho & Ki Hwa Yang

  3. Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Woon Kyu Lee & Kweon-Haeng Lee

  4. Department of Industrial Medicine, College of Medicine, Hanyang University, Seoul, Korea

    Yun Shin Kim

Authors
  1. Kyoung Ah Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yong-Yeun Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jung Sik Cho
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ki Hwa Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Woon Kyu Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kweon-Haeng Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yun Shin Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Young Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kim, K.A., Cho, YY., Cho, J.S. et al. Tumor necrosis factor-α gene promoter polymorphism in coal worker' pneumoconiosis. Mol Cell Biochem 234, 205–209 (2002). https://doi.org/10.1023/A:1015914409661

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1015914409661

search

Navigation