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Tumor necrosis factor-α gene promoter polymorphism in coal worker' pneumoconiosis

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Abstract

Tumor necrosis factor-alpha (TNF-α) is believed to play a central role in the pathogenesis of pneumoconiosis. TNF2, a polymorphism in the TNF-α gene promoter, has been associated with an increase in TNF-α production and airway inflammation. To investigate the frequency of TNF2 in patients who have coal workers' pneumoconiosis (CWP) and to determine whether it is associated with development of a large opacity in CWP, we investigated the expression of the TNF2 allele in 80 patients who had CWP and in 54 healthy controls using restriction fragment length polymorphism (RFLP). Compared to controls (10.2%), the frequency of the TNF2 allele was greater in the CWP patients (20.6%). Furthermore, the TNF2 allele was very common in patients who had a large opacity (28.2%) in comparison with 13.4% in those with simple CWP. From these data, we suggest that the TNF2 allele is associated with the development of a large opacity in CWP.

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Authors and Affiliations

  1. Department of Occupational and Environmental Medicine, St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea

    Kyoung Ah Kim & Young Lim

  2. Department of General Toxicology, Korea Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea

    Yong-Yeun Cho, Jung Sik Cho & Ki Hwa Yang

  3. Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Woon Kyu Lee & Kweon-Haeng Lee

  4. Department of Industrial Medicine, College of Medicine, Hanyang University, Seoul, Korea

    Yun Shin Kim

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  1. Kyoung Ah Kim
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Kim, K.A., Cho, YY., Cho, J.S. et al. Tumor necrosis factor-α gene promoter polymorphism in coal worker' pneumoconiosis. Mol Cell Biochem 234, 205–209 (2002). https://doi.org/10.1023/A:1015914409661

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