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A Statistical Approach for the Development of an Oral Controlled-Release Matrix Tablet

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Abstract

Tablet matrix compositions for optimized prolonged release were selected by surface response methodology. The extreme vertices experimental design was used to develop a surface response model which mathematically defined the release of active component from the tablet matrix as controlled by the percentage of the excipient components. The model, a statistical quadratic equation with a standard error of 3.3, was validated for accurate prediction of drug release profiles and used to identify optimum formulations. This study demonstrated a new application of the extreme vertices experimental design, an efficient method for evaluating a complex mixture system for controlled release, where specific constraints are placed on one or more of the components.

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REFERENCES

  1. R. A. McLean and V. L. Anderson. Technometrics 8:447–454 (1966).

    Google Scholar 

  2. V. E. McCurdy. The Effect of Microcrystalline Cellulose in a Sugar Coating Suspension on the Coating Process and on the Physical Properties of the Coated Tablets, Ph.D. thesis, Purdue University, West Lafayette, IN, 1985.

  3. R. D. Snee and D. W. Marquardt. Technometrics 16:399–408 (1974).

    Google Scholar 

  4. R. D. Snee. J. Qual. Tech. 3:159–169 (1971).

    Google Scholar 

  5. R. D. Snee. Technometrics 15:517–528 (1973).

    Google Scholar 

  6. V. L. Anderson and R. A. McLean. Design of Experiments: A Realistic Approach, Marcel Dekker, New York, 1974, pp. 342–347.

    Google Scholar 

  7. J. B. Schwartz. J. Soc. Cosmet. Chem. 32:287–301 (1981).

    Google Scholar 

  8. Handbook of Nonprescription Drugs, 6th ed. American Pharmaceutical Assoc., Washington, D.C., 1977, p. 90.

  9. D. P. Montgomery and E. A. Peck. Introduction to Linear Regression Analysis, John Wiley & Sons, Homewood, IL, 1983.

    Google Scholar 

  10. I. S. Kurotori. Ind. Quality Control 22:592–596 (1966).

    Google Scholar 

  11. J. W. Gorman. J. Qual. Tech. 2:186–194 (1970).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Pharmaceutical R&D, Pfizer Central Research, Eastern Point Road, Groton, Connecticut, 06340

    Alton D. Johnson

  2. Professor Emeritus, Department of Statistics, Purdue University, West Lafayette, Indiana, 47907

    Virgil L. Anderson

  3. Department of Industrial & Physical Pharmacy, Robert E. Heine School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana, 47907

    Garnet E. Peck

Authors
  1. Alton D. Johnson
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  2. Virgil L. Anderson
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  3. Garnet E. Peck
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Johnson, A.D., Anderson, V.L. & Peck, G.E. A Statistical Approach for the Development of an Oral Controlled-Release Matrix Tablet. Pharm Res 7, 1092–1097 (1990). https://doi.org/10.1023/A:1015911721455

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  • DOI: https://doi.org/10.1023/A:1015911721455

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