Abstract
The overall dehydration kinetics of prostaglandin El (PGE1) in a lipid emulsion at 35°C were found to fit a model whereby the k apparent measured at each pH is simply the sum of the product of the fraction of the PGE1 at the interface,f i, and the rate constant at the interface, k i, plus the product of the fraction of the PGE1 in the aqueous phase,f aq, and the rate constant in the aqueous phase, k aq. The values for f i and f aq were reported earlier as a function of pH at 35°C. The k aq and k apparent were experimentally determined as a function of pH at 35°C. The k i was indirectly determined from the stability data in the emulsion. Microscopic rate constants for dehydration of PGE1 in the aqueous phase and interface at 35°C were estimated from the experimental data. Based on the kinetic evaluation performed, it appears that the dehydration kinetics might be manipulated by the addition of charged surface active agents.
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Teagarden, D.L., Anderson, B.D. & Petre, W.J. Dehydration Kinetics of Prostaglandin E1 in a Lipid Emulsion. Pharm Res 6, 210–215 (1989). https://doi.org/10.1023/A:1015909432300
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DOI: https://doi.org/10.1023/A:1015909432300