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A Method to Predict the Percutaneous Permeability of Various Compounds: Shed Snake Skin as a Model Membrane

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Abstract

Penetration of various compounds through shed snake skin was measured in vitro to examine the effect of lipophilicity and molecular size of a compound on permeability through this model membrane. The permeabilities were found to be controlled by the lipophilicity and the molecular size of the permeant. The smaller and the more lipophilic the compound, the greater the permeability. Equations have been developed to predict the permeability from the molecular weight and the distribution coefficient of a compound. Further, the lipophilicity of shed snake skin is similar to that of human skin and the response of shed snake skin to the molecular size of a permeant is more similar to human skin than to hairless mouse skin. Considering the similarities between shed snake skin and human stratum coraeum in terms of structure, composition, and permeability characteristics, the same considerations may apply to permeability through human stratum corneum.

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Author notes

  1. Toshiaki Nishihata

    Present address: Upjohn Tsukuba Research Labs., 23 Wadai, Tsukuba-shi, Ibaraki-ken, 305, Japan

Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, 66045

    Tomoo Itoh, Ravi Magavi, Roger L. Casady, Toshiaki Nishihata & J. Howard Rytting

Authors
  1. Tomoo Itoh
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  2. Ravi Magavi
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  3. Roger L. Casady
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  4. Toshiaki Nishihata
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  5. J. Howard Rytting
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Itoh, T., Magavi, R., Casady, R.L. et al. A Method to Predict the Percutaneous Permeability of Various Compounds: Shed Snake Skin as a Model Membrane. Pharm Res 7, 1302–1306 (1990). https://doi.org/10.1023/A:1015902308676

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  • DOI: https://doi.org/10.1023/A:1015902308676

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