Effects of Adaptogens on Granulocytopoiesis during Paradoxical Sleep Deprivation


We studied the effects of extracts from Siberian ginseng, Rhodiola rosea, bergenia, and ginseng (G115) and pantohematogen on granulocytopoiesis after paradoxical sleep deprivation. The effects of adaptogens on the blood system were most pronounced during hyperplasia of granulocytopoiesis. Natural preparations were divided into groups depending on their activity. Extracts of Siberian ginseng and Rhodiola rosea did not modulate granulocytopoiesis. Ginseng G115 extract suppressed granulocytopoiesis. Bergenia extract and pantohematogen produced ambiguous effects on the granulocytic hemopoietic stem.

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  1. 1.

    M. G. Airapetyants and A. M. Vein, Neuroses in Experiments and Clinics [in Russian], Moscow (1982).

  2. 2.

    Yu. I. Vikhlyaev, T. A. Voronina, T. L. Garibova, et al., Phenazepam [in Russian], Kiev (1982), p. 452.

  3. 3.

    E. D. Gol'dberg, A. M. Dygai, and V. P. Shakhov, Tissue Cultures in Hematology [in Russian], Tomsk (1992), p. 272.

  4. 4.

    E. D. Gol'dberg, A. M. Dygai, L. A. Gur'yantseva, et al., Byull. Eksp. Biol. Med., 130, No. 11, 512–515 (2000).

    Google Scholar 

  5. 5.

    N. N. Demin, A. B. Kogan, and N. I. Moiseeva, Neurophysiology and Neurochemistry of Sleep [in Russian], Leningrad (1978), p. 192.

  6. 6.

    A. M. Dygai, E. G. Skurikhin, N. I. Suslov, et al., Byull. Eksp. Biol. Med., 126, No. 12, 628–631 (1998).

    Google Scholar 

  7. 7.

    M. D. Mashkovskii, Medicinal Preparations [in Russian], Vilnius (1993), Vol. 1, p. 542.

    Google Scholar 

  8. 8.

    V. A. Raiskii, Psychotropic Preparations in the Therapy of Internal Diseases [in Russian], Moscow (1982), p. 189.

  9. 9.

    E. G. Skurikhin, N. I. Suslov, N. V. Provalova, et al., Byull. Eksp. Biol. Med., 127, Suppl. 1, 7–11 (1999).

    Google Scholar 

  10. 10.

    E. G. Skurikhin, A. M. Dygai, N. I. Suslov, et al., Ibid., 131, No. 1, 43–47 (2001).

    Google Scholar 

  11. 11.

    A. A. Churin, Preparations of Baikal Skullcap as Correctors of Disturbances in Higher Nervous Activity and Blood Changes during Neuroses, Abstract of Cand. Sci. Med. Dissertation, Tomsk (1998).

  12. 12.

    C. Chinna, Osterreichische Apotheken-Zeitung, 46, No. 19, 377–381 (1992).

    Google Scholar 

  13. 13.

    M. Thakkar and B. N. Mallick, Sleep, 16, No. 8, 691–694 (1993).

    Google Scholar 

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Provalova, N.V., Skurikhin, E.G., Suslov, N.I. et al. Effects of Adaptogens on Granulocytopoiesis during Paradoxical Sleep Deprivation. Bulletin of Experimental Biology and Medicine 133, 261–264 (2002). https://doi.org/10.1023/A:1015890802157

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  • paradoxical sleep deprivation
  • granulocytopoiesis
  • adaptogens