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Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets

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Abstract

The effects of physical aging on the water permeation of cellulose acetate and ethylcellulose, the mechanical properties of ethylcellulose, and the dissolution property of hydroxypropyl methylcellulose phthalate were investigated. The water permeabilities of cellulose acetate and ethylcellulose and the dissolution rate of hydroxypropyl methylcellulose phthalate were found to decrease with physical aging time after being quenched from above the glass transition temperatures to sub-T g temperatures. The gradual approach toward thermodynamic equilibrium during physical aging decreases the free volume of the polymers. This decrease in free volume is accompanied by a decrease in the transport mobility, with concomitant changes in those properties of the polymer that depend on it. The effects of long-term aging on the dissolution rate and water permeabilities of these polymers can be estimated from a linear double-logarithmic relationship between the mobility properties and physical aging time. The existence of the linear double-logarithmic relationship can be derived from the Williams–Landel–Ferry (1) equation, the Doolittle (2) equation, Struik's (3) model, and Fujita's (4) relationship between diffusion and free volume.

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Author notes

  1. Jian-Hwa Guo

    Present address: The Upjohn Company, Kalamazoo, Michigan, 49001

Authors and Affiliations

  1. College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065

    Jian-Hwa Guo & Gordon L. Amidon

  2. Department of Materials Science and Engineering, The University of Michigan, Ann Arbor, Michigan, 48109-2136

    Richard E. Robertson

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  1. Jian-Hwa Guo
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  2. Richard E. Robertson
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  3. Gordon L. Amidon
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Guo, JH., Robertson, R.E. & Amidon, G.L. Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated Tablets. Pharm Res 8, 1500–1504 (1991). https://doi.org/10.1023/A:1015890232106

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