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Employing lonization Behaviors to Resolve a Trace-Level Impurity: Determination of l,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedi-carboxylic Acid Di-2-[methyl-(phenylmethyl)amino]ethyl Ester in Nicardipine Drug Substance

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Authors and Affiliations

  1. The Du Pont Merck Pharmaceutical Company, Pharmacy R&D, P.O. Box 80336, Wilmington, Delaware, 19880-0336

    Michael B. Maurin, Rodney D. Vickery & Munir A. Hussain

  2. The Du Pont Merck Pharmaceutical Company, Chemical Sciences, P.O. Box 80336, Wilmington, Delaware, 19880-0336

    Philip Ma & Joseph Manalo

Authors
  1. Michael B. Maurin
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  2. Rodney D. Vickery
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  3. Philip Ma
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  4. Joseph Manalo
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  5. Munir A. Hussain
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Maurin, M.B., Vickery, R.D., Ma, P. et al. Employing lonization Behaviors to Resolve a Trace-Level Impurity: Determination of l,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedi-carboxylic Acid Di-2-[methyl-(phenylmethyl)amino]ethyl Ester in Nicardipine Drug Substance. Pharm Res 9, 1518–1520 (1992). https://doi.org/10.1023/A:1015887602779

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