REFERENCES
British Pharmacopeia, University Press, Cambridge, England, 1980, Vol. l, p. 105.
Topical antifungal drug products for over-the-counter human use: Establishment of a monograph. Fed. Reg. 47:12533–12536 (1982).
W. C. Guess and M. K. Bruch. A review of available toxicity data on the topical antimicrobial, chloroxylenol. J. Toxicol. Cut. Ocular Toxicol. 5:233–262 (1986).
M. K. Bruch. The cutaneous absorption and systemic toxicity of antimicrobials. FDA concerns. In V. A. Drill and P. Lazar (eds.), Cutaneous Toxicity, Academic Press, New York, 1977, pp. 239–245.
D. Acosta, D. B. Mitchell, E. M. B. Sorensen, and J. V. Bruckner. The metabolism and toxicity of xenobiotics in a primary culture system of postnatal rat hepatocytes. In E. J. Rauckman and G. M. Padilla (eds.), The Isolated Hepatocyte, Academic Press, New York, 1987, pp. 189–214.
J. C. Davila, A. Lenherr, and D. Acosta. Protective effect of flavonoids on drug-induced hepatotoxicity in vitro. Toxicology 57:267–286 (1989).
D. Acosta, D. Anuforo, and R. V. Smith. Preparation of primary monolayer cultures of postnatal rat liver cells. J. Tiss. Cult. Meth. 6:35–37 (1980).
J. C. Davila, C. G. Reddy, P. J. Davis, and D. Acosta. Toxicity assessment of papaverine and papaverine-derived metabolites in primary cultures of rat hepatocytes. In Vitro Cell. Dev. Biol. 26:515–524 (1990).
B. Zondek and M. Finkelstein. Blood concentrations of pchloro-xylenol in man following parenteral, percutaneous and rectal application. Proc. Soc. Exp. Biol. Med. 61:200–202 (1946).
B. Zondek. Fate of halogenated phenols in the organism. Biomed. J. 37:592–595 (1943).
D. Meek, D. M. Piercy, and R. Gabriel. Fatal self-poisoning with Dettol. Post. Grad. Med. J. 53:229 (1977).
A. L. Lehninger. Biochemistry, Worth, New York, 1977.
S. Seifer and S. Englard. Energy metabolism. In I. M. Arias, W. B. Jakoby, H. Popper, D. Schachter, and D. A. Shafritz (eds.), The Liver: Biology andPathobiology, Raven Press, New York, 1988, pp. 279–315.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Davila, J.C., Dorantes, A., Stavchansky, S.A. et al. The Cytotoxicity of p-Chloro-m-xylenol in Primary Culture of Rat Hepatocytes. Pharm Res 8, 656–657 (1991). https://doi.org/10.1023/A:1015873227679
Issue Date:
DOI: https://doi.org/10.1023/A:1015873227679