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The Metabolism of CGP-291: The Use of Microorganisms as Models of Mammalian Metabolism

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Abstract

CGP-291 is an investigational antiprotozoal agent with unknown metabolism. Microbial systems were utilized, as a model of mammalian metabolism, to predict the oxidative metabolic pathway of this nitroimidazole. Large-scale fermentation of CGP-291 with Beauvaria bassiana produced two major metabolites, IV and V. Structures of both were elucidated by comparing spectral data of metabolites to that of the starting material. The presence of two minor monohydroxylated metabolites was verified using LC-MS.

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Authors and Affiliations

  1. Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677

    Tannis M. Jürgens & Alice M. Clark

  2. Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677

    Alice M. Clark

Authors
  1. Tannis M. Jürgens
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  2. Alice M. Clark
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Jürgens, T.M., Clark, A.M. The Metabolism of CGP-291: The Use of Microorganisms as Models of Mammalian Metabolism. Pharm Res 7, 742–745 (1990). https://doi.org/10.1023/A:1015871723330

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  • DOI: https://doi.org/10.1023/A:1015871723330

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