Abstract
The release of potassium chloride incorporated into hydrogenated vegetable oil and hydroxypropyl methylcellulose matrix tablets was studied in vitro. The formulations containing 20% hydrogenated vegetable oil and hydroxypropyl methylcellulose showed a sustained-release profile comparable to that of a standard commercially available sustained-release preparation, containing 8 mEq potassium chloride embedded in a wax material. The formulated and standard sustained-release potassium chloride tablets were compared to a conventional enteric-coated potassium chloride tablet in 10 healthy subjects. Mean recoveries in 24-hr urine potassium levels from four dosage forms (after subtracting normal urine potassium excretion levels) were 76 ± 32% from hydroxypropyl methylcellulose, 95 ± 22% from hydrogenated vegetable oil-incorporated matrix tablets, 91 ± 29% from commercially available sustained-release tablets, and 97 ± 13% from enteric-coated tablets. There was no significant difference (P > 0.05) in the time to reach maximum excretion rates among the three sustained-release tablets. No significant adverse effect was experienced with any of the preparations.
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REFERENCES
M. E. Kosman. Management of potassium problems during long-term diuretic therapy. JAMA 230:743–748 (1974).
S. O. Thier. Potassium physiology. Am. J. Med. 80 (Suppl. 4A):3–7 (1986).
S. J. Boley, A. C. Allen, L. Schultz, and S. Schwartz. Potassium-induced lesions of the small bowel. JAMA 193:997–1000 (1965).
L. Morgenstern, M. Freilich, and J. F. Panish. The circumferential small-bowel ulcer. JAMA 191:636–640 (1965).
D. R. Baker, W. H. Schrader, and C. R. Hitchcock. Small-bowel ulceration apparently associated with thiazide and potassium therapy. JAMA 190:586–590 (1964).
S. J. Boley, L. Schultz, H. Kreiger, S. Schwartz, A. Elguezabal, and A. C. Allen. Experimental evaluation of thiazides and potassium as a cause of small-bowel ulcer. JAMA 192:763–768 (1965).
V. Wynn. Potassium chloride and intestinal ulceration. Lancet 2:1241 (1965).
A. Rakhit, S. Melethil, J. D. Arnold, and W. E. Wagner. Kinetics of potassium excretion following oral supplements. Evidence of induced natriuresis. Pharm. Res. 4:531–535 (1987).
J. C. McLoughlin. Comparative effects of three delivery systems of oral potassium on upper gastrointestinal mucosa. Br. J. Clin. Pract. 41:865–868 (1987).
D. Ben-Ishay and K. Engelman. Bioavailability of potassium from a slow release tablet. Clin. Pharmacol. Ther. 14:250–258 (1973).
H. Moller, S. L. Ali, and D. Steinbach. Pharmaceutical and biological availability of sustained release preparations of potassium chloride. Int. J. Pharm. 7:157–167 (1980).
J. Arnold, J. T. Jacob, and B. Riley. Bioavailability and pharmacokinetics of a new slow release potassium chloride capsule. J. Pharm. Sci. 69:1416–1418 (1980).
C. J. Betlach, J. D. Arnold, R. W. Frost, P. T. Leese, and M. A. Gonzales. Bioavailability and pharmacokinetics of a new sustained release potassium chloride tablet. Pharm. Res. 4:409–411 (1987).
N. A. Peppas. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. 60:110–111 (1985).
N. A. Peppas and J. J. Sahlin. A simple equation for the description of solute release. III. Coupling of diffusion and relaxation. Int. J. Pharm. 57:169–172 (1989).
A. C. Cartwright and C. Shah. An in vitro dissolution test for slow release potassium chloride tablets. J. Pharm. Pharmacol. 29:367–369 (1977).
P. Muller, C. S. Qiao, J. Y. Pabst, and A. Stamm. Etude Comparative de Diverses Spécialités de Chlorure de Potassium á Libération Prolongée, Essais de Dissolution in Vitro, Proc. 5th Int. Conf. Pharm. Tech., APGI, Paris, 1989, Vol. I, pp. 380–389.
R. L. Tannen and A. Cordano. Pharmacokinetics and effects on fecal blood loss of a controlled release potassium chloride tablet. J. Pharmacol. Exp. Ther. 204:240–246 (1978).
V. A. Skoutakis, S. R. Acchiardo, N. J. Wojciechowski, C. A. Carter, A. P. Melikian, and A. N. Chremos. The comparative bioavailability of liquid, wax-matrix, and microencapsulated preparations of potassium chloride. J. Clin. Pharmacol. 25:619–621 (1985).
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Şenel, S., Çapan, Y., Dalkara, T. et al. Formulation, Bioavailability, and Pharmacokinetics of Sustained-Release Potassium Chloride Tablets. Pharm Res 8, 1313–1317 (1991). https://doi.org/10.1023/A:1015868232590
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DOI: https://doi.org/10.1023/A:1015868232590