Abstract
Hypersensitivity reactions to carboplatin are rare but sometimes life-threatening events may occur requiring discontinuation of treatment. In our study, we describe clinical features and diagnostic procedures of carboplatin-associated reactions in children affected by low-grade astrocytoma and treated with multiple courses of carboplatin. In 6 out of 29 children, we reported allergic events.
We also report a desensitization protocol for carboplatin administration, which allowed the patients to receive effective treatment without adverse reactions.
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References
Allen JC, Walker R, Luks E, Jennings M, Barfost S, Tan C: Carboplatin and recurrent childhood brain tumors. J Clin Oncol 5: 459-463, 1987
Chang SM, Fryberger S, Crouse V, Tilford D, Pradas MD: Carboplatin hypersensitivity in children. Cancer 75(1): 1171-1175, 1995
Cleare MJ, Hughes EG, Jacoby B, Pepys J: Immediate (type 1) allergic responses to platinum compounds. Clin Allergy 6: 183-195, 1976
Packer RJ, Lange B, Ater J, Nicholson HS, Allen J, Walker R, Prados M, Jakacki R, Reaman G, Needles MN, Phillips PC, Ryan J, Boyett JM, Geyer R, Finlay J: Carboplatin and vincristine for recurrent and newly diagnosed lowgrade gliomas of childhood. J Clin Oncol 11(5): 850-856, 1993
Windom HH, McGuire WP, Hamilton RG, Adkinson Jr NF: Anaphylaxis to carboplatin - a new platinum chemotherapeutic agent. J Allergy Clin Immunol 90(4): 681-683, 1992
Wiedmann B, Mulleneisen N, Boiko P, Niederle N: Hypersensitivity reactions to carboplatin. Cancer 73(8): 2218-2222, 1994
Shlebak AA, Clark PI, Green JA: Hypersensitivity and cross-reactivity to cisplatin and analogues. Cancer Chemother Pharmacol 35: 349-351, 1995
Saunders MP, Denton CP, O'Brein ME, Blake P, Gore M, Wiltshaw E: Hypersensitivity reactions to cisplatin and carboplatin - a report on six cases. Ann Oncol 3: 574-576, 1992
Planner RS, Weerasiri T, Timmins D, Grant P: Hypersensitivity reactions to carboplatin. J Natl Cancer Inst 23: 1763-1764, 1991
Sood AK, Gelder MS, Huang SW, Morgan LS: Anaphylaxis to carboplatin following multiple previous uncomplicated course. Gynecol Oncol 57: 131-132, 1995
Tonkin KS, Rubin P, Levin L: Carboplatin hypersensitivity: case reports and review of literature. Eur J Cancer 29A(9): 1356-1357, 1993
Freedman SO, Krupey J: Respiratory allergy caused by platinum salts. J Allergy 42: 233-237, 1968
Cromwell O, Pepys J, Parish WE, Hughes EG: Specific IgE anti-bodies to platinum salts in sensitized workers. Clin Allergy 9: 109-117, 1979
Schiavetti A, Varrasso G, Maurizi P, Castello MA: Hypersensitivity to carboplatin in children. Med Ped Oncol 32: 183-185, 1999
Goldberg A, Confino-Cohen R, Fishman A, Beyth J, Altaras M: A modified prolonged desensitization protocol in carboplatin allergy. J Allergy Clin Immunol 98: 841-843, 1996
Broome CB, Schiff RI, Friedman HS: Successful desensitization to carboplatin in patients with systemic hypersensitivity reactions. Med Ped Oncol 26: 105-110, 1996
Packer RJ, Ater J, Allen J, Phillips P, Geyer R, Nicholson HS, Jakacki R, Kurczynski E, Needle M, Finlay J, Reaman G, Boyett JM: Carboplatin and vincristine chemotherapy for childen with newly diagnosed progressive low-grade gliomas. J Neurosurg 86(5): 747-754, 1997
Silva MM, Goldman S, Keating G, Marymont MA, Kalapurakal J, Tomita T: Optic pathway hypothalamic gliomas in children under three years of age: the role of chemotherapy. Pediatr Neurosurg 33(3): 151-158, 2000
Gnekow AK, Kaatsch P, Kortmann R, Wiestler OD: HIT-LGG: effectiveness of carboplatin-vincristine in progressive low-grade gliomas of childhood - an interim report. Klin Padiatr 212(4): 177-184, 2000
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Lazzareschi, I., Ruggiero, A., Riccardi, R. et al. Hypersensitivity Reactions to Carboplatin in Children. J Neurooncol 58, 33–37 (2002). https://doi.org/10.1023/A:1015853200090
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DOI: https://doi.org/10.1023/A:1015853200090