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Kinetics of Drug Decomposition by Heat Conduction Calorimetry

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Abstract

The application of heat conduction calorimetry to the determination of decomposition mechanisms and rates for drugs is shown to be a rapid and generally useful method. The application of the method to determine the nature of the decomposition reaction, sources of systematic errors in the method, the equations relating the calorimetric signal to the kinetics of the reaction, and some examples of results are presented and discussed.

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Author notes

  1. Robert G. Bergstrom

    Present address: Baxter Healthcare Corporation, Route 120 and Wilson Road, Round Lake, Illinois, 60073

Authors and Affiliations

  1. Department of Chemistry, Brigham Young University, Provo, Utah, 84602

    Lee D. Hansen, Edwin A. Lewis & Delbert J. Eatough

  2. Department of Pharmaceutical Research, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, 19486

    Robert G. Bergstrom & Damans DeGraft-Johnson

Authors
  1. Lee D. Hansen
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  2. Edwin A. Lewis
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  3. Delbert J. Eatough
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  4. Robert G. Bergstrom
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  5. Damans DeGraft-Johnson
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Hansen, L.D., Lewis, E.A., Eatough, D.J. et al. Kinetics of Drug Decomposition by Heat Conduction Calorimetry. Pharm Res 6, 20–27 (1989). https://doi.org/10.1023/A:1015851100015

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  • DOI: https://doi.org/10.1023/A:1015851100015

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