Abstract
A new method for the detection of acute phlebitis in superficial veins is investigated. A thermographic camera is utilized for the quantitation of temperature changes in a rabbit ear model. A control group receiving no injection is compared against each of five treatment groups receiving these commercially available parenterals: amiodarone hydrochloride, phenytoin sodium, mechlorethamine hydrochloride, cephalothin sodium, and diazepam. The vehicles of the above-mentioned drugs as well as several commonly used organic cosolvents are also investigated. Local tissue responses to the parenteral challenges are measured and a good correlation between the visual and the thermographic data was seen.
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Ward, G.H., Nolan, P.E., Chawla, M. et al. Studies in Phlebitis: Detection and Quantitation Using a Thermographic Camera. Pharm Res 8, 76–79 (1991). https://doi.org/10.1023/A:1015834407748
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DOI: https://doi.org/10.1023/A:1015834407748