Abstract
This article reviews the recent biosensor developments for medical applications, focusing on the various biological recognition elements used in biosensors and the systems transduction mechanisms. Available instruments utilizing biosensor technology are also examined from a commercial perspective.
Similar content being viewed by others
REFERENCE
J. S. Schultz. Biosensors. Sci. Am. (2) (Aug.): 265, 64–69 (1991).
A. Athani and U. V. Banakar. The development and potential uses of biosensors. BioPharm 3(l):23–30 (1990).
F. Scheller et al. Research and development of biosensors. Analyst 114:653–662 (1989).
A. H. Free and H. M. Free. A simple test for urine bilirubin. Gastroenterologia 24:414–416 (1953).
L. C. Clark and C. Lyons. Electrode systems for continuous monitoring in cardiovascular surgery. Ann. N.Y. Acad. Sci. 102:29–45 (1962).
K. D. Mayer and B. J. Starkey. Simpler flame photometric determination of erythrocyte sodium and potassium: The reference range for apparently healthy adults. Clin. Chem. 23:275–278 (1977).
G. Eisenman. Glass Electrodes for Hydrogen and Other Ions, Marcel Dekker, New York 1967.
S. Lal and G. D. Christian. Response characteristics of the Orion potassium ion selective electrode. Anal. Lett. 3:11–15 (1970).
M. S. Frant and J. W. Ross Jr. Potassium ion specific electrode with high selectivity for potassium over sodium. Science 167:987–988 (1970).
L. A. Pioda, V. Stankova, and W. Simon. Highly selective potassium ion responsive liquid-membrane electrode. Anal. Lett. 2:665–674 (1969).
R. S. Cobbold. Transducers for Biomedical Measurements: Principles and Applications. Wiley, New York, 1974, pp. 322–403.
B. A. McKinley, J. Saffle, W. S. Jordan, J. Janata, S. D. Moss, and D. R. Westenskow. In vivo continuous monitoring of K+ in animals using ISFET probes. Med. Inst. 14:93–97 (1980).
B. Budesinsky and B. Menclova. Photometric determination of potassium with dinitrohydroxyazo. Chemist-Analyst 56:30–31 (1967).
J. N. Roe, F. C. Szoka, and A. S. Verkman. Colorimetric detection of alkali metals by ion-pair extraction. Appl. Spectrosc. 43:656–661 (1989).
A. Sanz-Medel, D. Blanco Gomis, and J. R. Garcia Alvarez. Ion-pair extraction and fluorometric determination of potassium with 18-crown-6 and eosin. Talanta 28:425–430 (1981).
C. L. Bashford, G. M. Alder, M. A. Gray, K. J. Micklem, C. C. Taylor, P. J. Turek, and C. A. Pasternak. Oxonol dyes as monitors of membrane potential. J. Cell. Physiol. 123:326–336 (1985).
S. Borman. Optical and piezoelectric biosensors. Anal. Chem. 59:1161A–1164A (1987).
B. P. H. Schaffar and O. S. Wolfbeis. Effect of Langmuir-Blodgett layer composition on the response of ion-selective optrodes for potassium, based on the fluorometric measurement of membrane potential. Analyst 113:693–697 (1988).
J. F. Alder, D. C. Ashworth, R. Narayanaswamy, R. E. Moss, and I. O. Sutherland. An optical potassium ion sensor. Analyst 112:1191–1192 (1987).
J. N. Roe, F. C. Szoka, and A. S. Verkman. A fiberoptic sensor for potassium detection using fluorescence energy transfer. Analyst 115:353–358 (1990).
E. Prusak-Sochaczewski, J. Luong, and G. Guilbault. Development of a piezoelectric immunosensor for the detection of Salmonella typhimurium. Enzyme Microbial Technol. 12(3):173–177 (1990).
E. Prusak-Sochaczewski and J. Luong. Detection of human transferrin by the piezoelectric crystal. Anal. Lett. 23(2):183–194 (1990).
D. Monroe. Potentiometric immunoassay. Am. Biotechnol. Lab. Nov.–Dec.:28–40 (1986).
M. S. Abdel-Latif, A. Suleiman, G. G. Guilbault, B. A. A. Dremel, and R. D. Schmid. Fiber optic sensors: Recent developments. Anal. Lett. 23(3):375–399 (1990).
M. A. Arnold. Fiber optic biosensing probes for biomedically important compounds. SPIE 906:128–133 (1988).
J. S. Schultz, S. Mansouri, and I. J. Goldstein. Affinity sensor: A new technique for developing implantable sensors for glucose and other metabolites. Diabetes Care 5(3):245–253 (1982).
T. Vo-Dinh, T. Nolan, Y. F. Cheng, M. J. Sepaniak, and J. P. Alarie. Phase-resolved fiber-optics fluoroimmunosensor. Appl. Spectrosc. 44:128–132 (1990).
J. T. Ives, J. N. Lin, and J. D. Andrade. Fiber-optic fluorescence immunosensors. Am. Biotechnol. Lab. March: 10–18 (1989).
G. Kampfrath and R. Hintsche. Plasma-polymerized thin films for enzyme immobilization in biosensors. Anal. Lett. 22(11–12): 2423–2431 (1989).
R. Hintsche, G. Neumann, I. Dransfeld, G. Kampfrath, B. Hoffmann, and F. Scheller. Polyurethane enzyme membranes for chip biosensors. Anal. Lett. 22(9):2175–2190 (1989).
C. Galiatsatos, K. Haljizadeh, J. E. Mark, and W. R. Heineman. A new method for enzyme membrane preparation based on polyurethane technology: Electrode modification for sensor development. Biosensors 4(6):393–402 (1989).
J. Anzai, S. Lee, and T. Osa. Enzyme sensors based on an ion-sensitive field effect transistor coated with Langmuir-Blodgett membranes. Chem. Pharm. Bull. 37(12):3320–3322 (1989).
B. H. Schneider, M. R. S. Hill, and O. J. Prohaska. Microelectrode probes for biomedical applications. Am. Biotechnol. Lab. Feb.: 17–23 (1990).
J. E. Frew and M. J. Green. Amperometric biosensors. Anal. Proc. (London) 26(10):344–352 (1989).
D. Monroe. Novel implantable glucose sensors. Am. Clin. Lab. 8(12):8–16 (1989).
V. L. Davidson. Quinoproteins: A new class of enzymes with potential use as biosensors. Am. Biotechnol. Lab. Feb.:32–34 (1990).
M. Y. K. Ho and G. A. Rechnitz. Highly stable biosensor using an artificial enzyme. Anal. Chem. 59:536–537 (1987).
S. J. Lasky and D. A. Buttry. Development of a real-time glucose biosensor by enzyme immobilization on the quartz crystal microbalance. Am. Biotechnol. Lab. Feb.:8–16 (1990).
M. J. Muehlbauer, E. J. Guilbeau, and B. C. Towe. Model for a thermoelectric enzyme glucose sensor. Anal. Chem. 61:77–83 (1989).
S. F. Hallowell and G. A. Rechnitz. Enzyme amplified receptor assay (ERA): A novel approach to drug detection. Anal. Lett. 20(12):1929–1949 (1987).
T. J. Kulp, I. Camins, S. M. Angel, C. Munkholm, and D. R. Walt. Polymer immobilized enzyme optrodes for the detection of penicillin. Anal. Chem. 59:2849–2853 (1987).
S. Luo and D. R. Walt. Avidin-biotin coupling as a general method for preparing enzyme-based fiber-optic sensors. Anal. Chem. 61:1069 (1989).
B. S. Walter, T. J. Nielsen, and M. A. Arnold. Fiber-optic biosensor for ethanol based on an internal enzyme concept. Talanta 35:151–155 (1988).
W. Trettnak and O. S. Wolfbeis. A fiberoptic cholesterol biosensor with an oxygen optrode as the transducer. Anal. Biochem. 184(1): 124–127 (1989).
L. J. Blum, S. M. Gautier, and P. R. Coulet. Highly stable bioluminescence-based fiber-optic sensor using immobilized enzymes from Vibrio harveyi. Anal. Lett. 22(10):2211–2222 (1989).
S. A. Glazier and G. A. Rechnitz. Construction and characterization of beet stem based biosensors for oxalate. Anal. Lett. 22(15):2929–2948 (1989).
I. Karube, K. Hiramoto, M. Kawarai, and K. Sode. Biosensors for toxic compounds using immobilized animal cell membrane. Maku 14(5):311–318 (1989).
Y. Sato, K. Chikyu, and K. Kobayakawa. Amino acid and urea sensors using parsley leaves as catalytic material. Chem. Lett. 7:1305–1308 (1989).
G. A. Rechnitz. Biosensors. Chem. Eng. News Sept. 5:24–36 (1988).
R. M. Buch and G. A. Rechnitz. Intact chemoreceptor-based biosensors: extreme sensitivity to some excitatory amino acids. Anal. Lett. 22(13–14):2685–2702 (1989).
M. Gotoh, E. Tamiya, M. Momoi, Y. Kagawa, and I. Karube. Acetylcholine sensor based on ion sensitive field effect transistors and acetylcholine receptors. Anal. Lett. 20:857–870 (1987).
J. L. Marty, K. Sode, and I. Karube. Amperometric determination of choline and acetylcholine with enzymes immobilized in a photocross-linkable polymer. Anal. Chem. Acta 228:49–53 (1990).
E. Ohashi, E. Tamiya, and I. Karube. A new enzymatic receptor to be used in biosensors. J. Membr. Sci. 49:95–102 (1990).
M. E. Collison and M. E. Meyerhoff. Chemical sensors for bedside monitoring of critically ill patients. Anal. Chem. 62:425A–437A (1990).
C. Starrs. Technology rises to the ocassion: The growth of home testing. Clin. Lab. Sci. 2:330–336 (1989).
B. Walter. Dry reagent chemistries. Anal. Chem. 55:498A–514A (1983).
J. Hanlin. Thin films: New medical detectives. Photon. Spectra Feb.:113–118 (1988).
S. M. Miller and P. Etnyre-Zacher. Biosensors and diagnostic testing: Enzyme electrodes. Clin. Lab. Sci. 2(3):169–173 (1989).
The U.S. Market for Smart Sensors. Frost and Sullivan, Inc., A-2641, 1989.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Roe, J.N. Biosensor Development. Pharm Res 9, 835–844 (1992). https://doi.org/10.1023/A:1015828311073
Issue Date:
DOI: https://doi.org/10.1023/A:1015828311073