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Pharmaceutical Research

, Volume 8, Issue 5, pp 658–660 | Cite as

Low First-Spray Drug Content in Albuterol Metered-Dose Inhalers

  • Terry D. Cyr
  • Susan J. Graham
  • K. Y. Robert Li
  • Edward G. Levering
Note
metered-dose inhalers albuterol content uniformity unit spray aerosol 

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REFERENCES

  1. 1.
    United States Pharmacopeia, 22nd rev., United States Pharmacopeial Convention, Inc., Rockville, MD, 1990, pp. 1617–1619.Google Scholar
  2. 2.
    N. Beaulieu, T. D. Cyr, and E. G. Lovering. HPLC methods for the determination of albuterol (salbutamol), albuterol sulfate and related compounds in drug raw material, tablets and inhalers. J. Pharm. Biomed. Anal. 8:583–589 (1990).Google Scholar
  3. 3.
    Compendium of Pharmaceuticals and Specialties, 24th ed., Canadian Pharmaceutical Association, Ottawa, 1989.Google Scholar
  4. 4.
    E. F. Fiese, W. G. Gorman, D. Dolinsky, R. J. Harwood, W. A. Hunke, N. C. Miller, H. Mintzer, and N. J. Harper. Test method for evaluation of loss of prime in metered dose aerosols. J. Pharm. Sci. 77:90–93 (1988).Google Scholar

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Terry D. Cyr
    • 1
  • Susan J. Graham
    • 1
  • K. Y. Robert Li
    • 1
  • Edward G. Levering
    • 1
  1. 1.Bureau of Drug Research, Health Protection BranchOttawaCanada

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