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Estimate of Volume/Flow Ratio of Gastrointestinal (GI) Fluids in Humans Using Pharmacokinetic Data

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Abstract

Based on the mixing tank and tube models for drug absorption, the apparent absorption rate constant is shown to be related to the fraction of dose absorbed as a function of the volume/flow ratio of GI fluids. This analysis applies to drugs that are absorbed according to first-order kinetics, without limitation by dissolution rate, lumenal decomposition, or first-pass metabolism. Analysis of pharmacokinetic data of drugs that fit these criteria and are absorbed to varying extents enabled the estimation of the volume/flow ratio of GI fluids in humans; it was found to be 1.6 ± 0.3 (SE) hr using a mixing tank model and 0.32 ± 0.05 hr using a tube model. These findings are discussed with respect to volume and flow parameters used in the design of various types of drug absorption studies.

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Authors and Affiliations

  1. Department of Pharmacy, University of Athens, Athens, 10680, Greece

    Panayotis Macheras & Christos Reppas

  2. College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109

    Jennifer B. Dressman

Authors
  1. Panayotis Macheras
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  2. Christos Reppas
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  3. Jennifer B. Dressman
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Macheras, P., Reppas, C. & Dressman, J.B. Estimate of Volume/Flow Ratio of Gastrointestinal (GI) Fluids in Humans Using Pharmacokinetic Data. Pharm Res 7, 518–522 (1990). https://doi.org/10.1023/A:1015825018361

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