Abstract
Choroid plexus carcinomas (CPC) are rare central nervous system malignancies. While attempted surgical resection is imperative, the benefit of adjuvant therapy, particularly in the setting of a gross total resection (GTR), is unclear. We reviewed all pediatric cases of CPC reported in the literature between 1985 and 2000. Seventy-five cases of CPC were identified. Mean age at the time of diagnosis was 26 months. Thirty-seven patients had a GTR and 38 patients had a subtotal resection (STR). Thirty-eight cases (51%) were alive and 37 cases (49%) were deceased at time of publication. For cases with a GTR, survival was 84% compared to an 18% survival for patients with a STR. For patients with a GTR, all forms of adjuvant therapy were statistically equivalent. Our retrospective literature review confirms the importance of GTR in the therapy of CPC, with GTR alone being the single most important predictor of survival. The prognosis is poor for any patient with a STR, with the exception of those patients for whom adjuvant therapy allowed for an eventual GTR. The small number of patients receiving a GTR and no further therapy precluded a statistical comparison of no therapy in the setting of a GTR versus any form of adjuvant therapy. However, all four of these patients are alive, raising the possibility that adjuvant therapy in the setting of a GTR may not be required.
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Janisch W, Staneczek W: Primary tumors of the choroid plexus. Frequency, localization and age. Zentralbl Allg Pathol 135: 235-240, 1989
Berger C, Thiesse P, Lellouch-Tubiana A, Kalifa C, Pierre-Kahn A, Bouffet E: Choroid plexus carcinomas in childhood: clinical features and prognostic factors. Neurosurgery 42: 470-475, 1998
Ellenbogen RG, Winston KR, Kupsky WJ: Tumors of the choroid plexus in children. Neurosurgery 25: 327-335, 1989
Duffner PK, Kun LE, Burger PC, Horowitz ME, Cohen ME, Sanford RA, Krischer JP, Mulhern RK, James HE, Rekate HL: Postoperative chemotherapy and delayed radiation in infants and very young children with choroid plexus carcinomas. The Pediatric Oncology Group. Pediatr Neurosurg 22: 189-196, 1995
Allen J, Wisoff J, Helson L, Pearce J, Arenson E: Choroid plexus carcinoma-responses to chemotherapy alone in newly diagnosed young children. J Neuro-Oncol 12: 69-74, 1992
Weitzman S, Greenberg M, Becker L, Hoffman H: Choroid plexus carcinoma-response to neoadjuvant combination chemotherapy. Pediatr Neurosci 14: 165, 1988
Razzaq AA, Cohen AR: Neoadjuvant chemotherapy for hypervascular malignant brain tumors of childhood. Pediatr Neurosurg 27: 296-303, 1997
Souweidane MM, Johnson JH Jr, Lis E: Volumetric reduction of a choroid plexus carcinoma using preoperative chemotherapy. J Neuro-Oncol 43: 167-171, 1999
Arico M, Raiteri E, Bossi G, Giordana MT, Corbella F, Locatelli D, Pezzotta S: Choroid plexus carcinoma: report of one case with favourable response to treatment. Med Pediatr Oncol 22: 274-278, 1994
Bennedbaek O, Therkildsen MH: Choroid plexus carcinoma-report of a case with metastases within the central nervous system. Acta Oncol 29: 241-243, 1990
Wolff JE, Sajedi M, Coppes MJ, Anderson RA, Egeler RM: Radiation therapy and survival in choroid plexus carcinoma (letter). Lancet 353: 2126, 1999
Kumabe T, Tominaga T, Kondo T, Yoshimoto T, Kayama T: Intraoperative radiation therapy and chemotherapy for huge choroid plexus carcinoma in an infant-case report. Neurol Med Chir (Tokyo) 36: 179-184, 1996
St. Clair SK, Humphreys RP, Pillay PK, Hoffman HJ, Blaser SI, Becker LE: Current management of choroid plexus carcinoma in children. Pediatr Neurosurg 17: 225-233, 1991
Geerts Y, Gabreels F, Lippens R, Merx H, Wesseling P: Choroid plexus carcinoma: a report of two cases and review of the literature. Neuropediatrics 27: 143-148, 1996
Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR: Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors (see comments). N Engl J Med 328: 1725-1731, 1993
Adams RW Jr: Choroid plexus carcinoma: report of a case with radiographic and ultrastructure correlation. J Am Osteopath Assoc 86: 279-284, 1986
Yuasa H, Tokito S, Tokunaga M: Primary carcinoma of the choroid plexus in Li-Fraumeni syndrome: case report. Neurosurgery 32: 131-133; discussion 133-134, 1993
Kang HS, Wang KC, Kim YM, Kim IO, Kim SK, Chi JG, Cho BK: Choroid plexus carcinoma in an infant. J Korean Med Sci 12: 162-167, 1997
Packer RJ, Perilongo G, Johnson D, Sutton LN, Vezina G, Zimmerman RA, Ryan J, Reaman G, Schut L: Choroid plexus carcinoma of childhood. Cancer 69: 580-585, 1992
Pierga JY, Kalifa C, Terrier-Lacombe MJ, Habrand JL, Lemerle J: Carcinoma of the choroid plexus: a pediatric experience. Med Pediatr Oncol 21: 480-487, 1993
Shinoda J, Kawaguchi M, Matsuhisa T, Deguchi K, Sakai N: Choroid plexus carcinoma in infants: report of two cases and review of the literature. Acta Neurochir (Wien) 140: 557-563, 1998
Griffin BR, Stewart GR, Berger MS, Geyer JR, O'Dell M, Rostad S: Choroid plexus carcinoma of the fourth ventricle. Report of a case in an infant. Pediatr Neurosci 14: 134-139, 1988
Greenberg ML: Chemotherapy of choroid plexus carcinoma. Childs Nerv Syst 15: 571-577, 1999
Newbould MJ, Kelsey AM, Arango JC, Ironside JW, Birch J: The choroid plexus carcinomas of childhood: histopathology, immunocytochemistry and clinicopathological correlations. Histopathology 26: 137-143, 1995
Chow E, Jenkins JJ, Burger PC, Reardon DA, Langston JW, Sanford RA, Heideman RL, Kun LE, Merchant TE: Malignant evolution of choroid plexus papilloma. Pediatr Neurosurg 31: 127-130, 1999
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Fitzpatrick, L.K., Aronson, L.J. & Cohen, K.J. Is there a Requirement for Adjuvant Therapy for Choroid Plexus Carcinoma that has been Completely Resected?. J Neurooncol 57, 123–126 (2002). https://doi.org/10.1023/A:1015773624733
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DOI: https://doi.org/10.1023/A:1015773624733