Abstract
Complex formation equillibria of [Pd(DAP)(H2O)2]2+ (DAP = 1,3-diaminopropane) with Cl−, OH−, cyclobutane dicarboxylic acid (CBDCA), amino acids, peptides and DNA unit constituents have been investigated. Stoichiometries and stability constants of the complexes were determined at 37°C and 0.16 M NaNO3 ionic strength. The results showed the formation of 1:1 complexes with amino acids and CBDCA. Peptides form both 1:1 complexes and the corresponding deprotonated amide species. DNA constituents form both 1:1 and 1:2 complexes. [Pd(DAP)(CBDCA)] was isolated and characterized. The concentration distribution of the complexes in solution was evaluated.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
I. H. Krakoft, in M. Nicolini (Ed.), Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy: Clinical Application of Platinum Complexes, Martinus Nijhoff Publishing, Boston, MA, 1988, p. 351.
P. J. Loehrer and L. H. Einhorn, Ann. Intern. Med., 100, 704 (1984).
J. B. Vermorken and H. M. Pinedos, Neth. J. Med., 25, 270 (1982).
D. D. Vonhoff, R. Schilsky and C. M. Reichert, Cancer Treat. Rep., 63, 1527 (1979).
S. J. Harland, I. E. Smith, N. Smith and D. L. Alison, in H. P. Hacker, E. P. Douple and I. H. Krakoft (Eds.), Platinum Coordination Complexes in Cancer Chemotherapy, Martinus Nijhoff Publishing, Boston, MA, 1984, p. 352.
M. J. Egorin, D. A. van Echo, E. A. Ohman, M. Y. Whiteacre, A. Forrest and J. Aisner, Cancer Res., 45, 6502 (1985).
K. J. Barnham, M. I. Djuran, U. Frey, M. A. Mazid and P. J. Sadler, J. Chem. Soc., Chem. Commun., 65 (1994).
K. J. Barnham, C. J. Bauer, M. I. Djuran, M. A. Mazid, T. Rau and P. J. Sadler, Inorg. Chem., 34, 2826 (1995).
M. M. Shoukry and R. van Eldik, J. Chem. Soc., Dalton Trans., 2673 (1996).
M. M. Shoukry, H. Hohmann and R. van Eldik, Inorg. Chim. Acta, 187, 198 (1992).
T. Rau, M. M. Shoukry and R. van Eldik, Inorg. Chem., 36, 1454 (1997).
M. M. Shoukry, I. M. Kenawy and I. H. El-haj, Transition Met. Chem., 16, 637 (1991).
M. M. Shoukry, E. M. Khairy and A. Saeed, J. Coord. Chem., 17, 305 (1988).
G. Mahal and R. van Eldik, Inorg. Chem., 24, 4165 (1985).
R. G. Bates, Determination of pH-Theory and Practice, 2nd Edit., Wiley Interscience, New York, 1975.
M. M. Shoukry, M. M. Hosny and M. Khalil, Transition Met. Chem., 20, 252 (1995).
M. Schmulling, A. D. Ryabov and R. van Eldik, J. Chem. Soc., Dalton Trans., 1257 (1994).
P. Gans, A. Subatini and A. Vacca, Inorg. Chim. Acta. 18, 237 (1976).
L. Pettit (University of Leeds), Personal communication.
R. B. Martin, in S. J. Lippard (Ed.), Platinum, Gold and Other Metal Chemotherapeutic Agents, ACS Symp. Ser. 1983, 209, 240.
S. E. Miller and D. A. House, Inorg. Chim. Acta, 161, 131 (1989).
M. C. Lim, J. Chem. Soc., Dalton Trans., 15 (1977).
K. Maskos, Acta Biochem. Pol., 28, 317 (1981).
K. Maskos, J. Inorg. Biochem., 25, 1 (1985).
B. Noszal, V. Scheller-Krattiger and R. B. Martin, J. Am. Chem. Soc., 104, 1078 (1982).
D. J. Hodgson, Prog. Inorg. Chem., 23, 211 (1977).
L. G. Marzilli, Prog. Inorg. Chem., 23, 255 (1977).
B. Taqui Khan, M. R. Raju and S. M. Zakeeruddin, J. Coord. Chem., 16, 237 (1987).
N. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination compounds, Wiley, New York, 1986.
U. Frey, J. D. Ranford and P. J. Sadler, Inorg. Chem., 32, 1333 (1993).
K. J. Barnham, M. I. Djuran, U. Frey, M. A. Mazid and P. J. Sadler, J. Chem. Soc., Chem. Commun., 65 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
El-Medani, S.M., Shohayeb, S.M. & Shoukry, M.M. Equilibrium studies of complex formation involving palladium(II)-(1,3-diaminopropane) and cyclobutane dicarboxylic acid, DNA units, amino acids or peptides. Transition Metal Chemistry 23, 287–293 (1998). https://doi.org/10.1023/A:1015712901496
Issue Date:
DOI: https://doi.org/10.1023/A:1015712901496