Abstract
Reports of studies relating physical activity to stroke and cancer sub-types indicate inconsistent findings. Some are hampered by low statistical power, owing to a low number of events, and a failure to adjust for potential confounding variables. The purpose of this study was to relate physical activity to 12 mortality endpoints in a prospective cohort study of 11,663 men aged 40–64 years who responded to an enquiry about travel activity during a baseline medical examination conducted between 1967 and 1969. During 25 years of follow-up there were 4672 deaths. Travel activity was inversely related to mortality attributable to all-causes, coronary heart disease, respiratory disease and lung cancer, whereas the association with stroke was positive. There was evidence for attenuation of some of these associations on adjustment for potentially confounding variables. Our simplistic measure of physical activity may, in part, explain the weak associations seen.
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References
Berlin A, Colditz GA. A meta-analysis of physical activity in the prevention of coronary heart disease. Am J Epidemiol 1990; 132: 612–628.
Eaton CB. Relation of physical activity and cardiovascular fitness to coronary heart disease, part I: A meta-analysis of the independent relation of physical activity and coronary heart disease. J Am Board Fam Pract 1992; 5: 31–42.
US Department of Health and Human Services. The effects of physical activity on health and disease. Physical Activity and Health: A report of the Surgeon General, Atlanta, US: US Department of Health and Human Services, 1996, pp 85–172.
Batty GD. Physical activity and coronary heart disease in older adults – a review of epidemiological studies. Eur J Public Health (in press).
Oliveria SA, Lee I-M. Is exercise bene.cial in the prevention of prostate cancer? Sports Med 1997; 23: 271–278.
Batty GD, Thune I. Does physical activity prevent cancer? Evidence suggests protection against colon cancer and probably breast cancer (editorial). BMJ 2000; 321: 1424–1425.
Davey Smith G, Shipley MJ, Batty GD, Morris JN, Marmot M. Physical activity and cause-specific mortality in the Whitehall study. Public Health 2000; 114: 308–315.
Polednak AP. College athletics, body size, and cancer mortality. Cancer 1976; 38: 382–387.
Colditz GA, Cannuscio CC, Frazier AL. Physical activity and reduced risk of colon cancer. Cancer Causes Control 1997; 8: 649–667.
Reid DD, Hamilton PJS, McCartney P, Rose G, Jarrett RJ, Keen H et al. Cardiorespiratory disease and diabetes among middle-aged male civil servants. Lancet 1974; i: 469–473.
Rose GA. The diagnosis of ischaemic heart pain and intermittent claudication in field studies. Bull World Health Org 1962; 27: 645–658.
Committee on the aetiology of chronic bronchitis. Definition and classification of chronic bronchitis. Lancet 1965; i: 775–779.
Rose GA, Holland WW, Crowley EA. A sphygmomanometer for epidemiologists. Lancet 1964; i: 296–300.
Rose GA. The coding of survey electrocardiograms by technicians. Br Heart J 1965; 27: 595–598.
Rose GA, Blackburn H. Cardiovascular Survey Methods (WHO Monograph Series no. 56). Geneva: WHO, 1968.
Cox DR. Regression models and life-tables. J R Stat Soc B 1972; 34: 187–220.
Lee I-M, Paffenbarger RS, Hennekens CH. Physical activity, physical fitness and longevity. Aging Clin Exp Res 1997; 9: 2–11.
Lee I-M, Paffenbarger RS. Physical activity and stroke incidence. Stroke 1998; 29: 2049–2054.
Lee I-M, Hennekens CH, Berger K, Buring JE, Manson JE. Exercise and risk of stroke in male physicians. Stroke 1999; 30: 1–6.
Evenson KR, Rosamond WD, Cai J, Toole JF, Hutchinson RG, Shahar E, et al. Physical activity and ischemic stroke risk. Stroke 1999; 30: 1333–1339.
Agnarsson U, Thorgeirsson G, Sigvaldason H, Sigfusson N. Effects of leisure-time physical activity and ventilatory function on risk for stroke in men: the Reykjavik Study. Ann Int Med 1999; 130: 987–990.
Strachan DP. Ventilatory function as a predictor of stroke. BMJ 1991; 302: 84–87.
Oliveria SA, Christos PJ. The epidemiology of physical activity and cancer. Ann NY Acad Sci 1997; 833: 79–90.
Thune I, Lund E. The influence of physical activity on lung-cancer risk. Int J Cancer 1997; 70: 57–62.
Wareham NJ, Rennie KL. The assessment of physical activity in individuals and populations: Why try to be more precise about how physical activity is assessed? Int J Obes 1998; 22(Suppl 2): S30–S38.
Lee I-M, Paffenbarger RS, Hsieh CC. Time trends in physical activity among college alumni 1962–1988. Am J Epidemiol 1992; 135: 915–925.
Garcia-Palmieri MR, Costas R, Cruz-Vidal M, Sorlie PD, Havlik RJ. Increased physical activity: A protective factor against heart attacks in Puerto Rico. Am J Cardiol 1982; 50: 749–755.
Batty GD. The relation of cardio-respiratory fitness and physical activity to coronary heart disease, stroke and site-specific cancers: evidence from two prospective cohort studies. PhD thesis. University of Bristol. 1999.
Davey Smith G. Reflections on the limitations of epidemiology. J Clin Epidemiol 2001; 54: 325–331.
Batty GD, Leon DA. Socio-economic position and coronary heart disease risk factors in children and young people – evidence from UK epidemiological studies. Eur J Public Health (in press).
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Batty, G.D., Shipley, M.J., Marmot, M. et al. Physical activity and cause-specific mortality in men: Further evidence from the Whitehall study. Eur J Epidemiol 17, 863–869 (2001). https://doi.org/10.1023/A:1015609909969
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DOI: https://doi.org/10.1023/A:1015609909969