Hydrogenation on Granular Palladium-containing Catalysts: II. Hydrogenation of Nitroheterocyclic Compounds

Abstract

Nitroheterocyclic compounds were reduced in a classical reactor with an agitator equipped with a cell for fixed bed of catalyst. As catalysts were applied granular palladium catalysts (0.5% of Pd on γ-Al₂O₃ and 2% of Pd on granulated carbon). Anilines and 3-amino-2(1H)-pyridones were obtained in high yield at reduction of the appropriate nitro compounds, and the activity of the catalyst samples only slightly decreased. Yet aminopyrazoles and aminoimidazoles obtained by hydrogenation on palladium were very sensitive to the presence of air even as hydrochlorides. In the course of hydrogenation of nitropyrazoles and nitroimidazoles the activity of the catalyst markedly decreased.