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Effects of Selank on Behavioral Reactions and Activities of Plasma Enkephalin-Degrading Enzymes in Mice with Different Phenotypes of Emotional and Stress Reactions

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Abstract

Comparative study of plasma activities of enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions revealed significant differences between intact BALB/c and C57Bl/6 mice by the half-life of plasma leu-enkephalin. Selank in a dose of 100 μ/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice, but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice. Our results suggest that anxiolytic activity of Selank is associated with inhibition of enkephalin-degrading enzymes.

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Authors and Affiliations

  1. Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow

    O. Yu. Sokolov, V. K. Meshavkin, N. V. Kost & A. A. Zozulya

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  1. O. Yu. Sokolov
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  2. V. K. Meshavkin
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  3. N. V. Kost
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  4. A. A. Zozulya
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Correspondence to O. Yu. Sokolov.

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Sokolov, O.Y., Meshavkin, V.K., Kost, N.V. et al. Effects of Selank on Behavioral Reactions and Activities of Plasma Enkephalin-Degrading Enzymes in Mice with Different Phenotypes of Emotional and Stress Reactions. Bulletin of Experimental Biology and Medicine 133, 133–135 (2002). https://doi.org/10.1023/A:1015582302311

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  • DOI: https://doi.org/10.1023/A:1015582302311

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