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Activation of Cannabinoid Receptors Decreases the Area of Ischemic Myocardial Necrosis

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Abstract

We studied the possibility of decreasing the area of ischemic necrosis during myocardial infarction with HU-210, a selective cannabinoid receptor agonist. Activation of cannabinoid receptors with HU-210 had practically no effect on collateral blood flow in the myocardium, but considerably decreased the area of necrosis. There results indicate that cannabinoid receptor agonist HU-210 possesses cardioprotective activity and delays the formation of necrotic zones during coronary occlusion and reperfusion.

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Authors and Affiliations

  1. Tomsk State Pedagogical University, Russia

    D. S. Ugdyzhekova, A. V. Krylatov, N. A. Bernatskaya, L. N. Maslov, R. Mechoulam & R. G. Pertwee

  2. Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia

    D. S. Ugdyzhekova, A. V. Krylatov, N. A. Bernatskaya, L. N. Maslov, R. Mechoulam & R. G. Pertwee

  3. Jerusalem University, Israel

    D. S. Ugdyzhekova, A. V. Krylatov, N. A. Bernatskaya, L. N. Maslov, R. Mechoulam & R. G. Pertwee

  4. Aberdeen University, Aberdeen, United Kingdom

    D. S. Ugdyzhekova, A. V. Krylatov, N. A. Bernatskaya, L. N. Maslov, R. Mechoulam & R. G. Pertwee

Authors
  1. D. S. Ugdyzhekova
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  2. A. V. Krylatov
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  3. N. A. Bernatskaya
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  4. L. N. Maslov
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  5. R. Mechoulam
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  6. R. G. Pertwee
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Ugdyzhekova, D.S., Krylatov, A.V., Bernatskaya, N.A. et al. Activation of Cannabinoid Receptors Decreases the Area of Ischemic Myocardial Necrosis. Bulletin of Experimental Biology and Medicine 133, 125–126 (2002). https://doi.org/10.1023/A:1015526217332

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  • DOI: https://doi.org/10.1023/A:1015526217332

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