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Synthesis of (7-polyfluoroalkyl)pyrazolo[1,5-a]pyrimidines based on lithium fluorine-containing β-diketonates

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Abstract

The reactions of Li enolates of fluorine-containing β-diketones with 3-aminopyrazoles afforded (7-polyfluoroalkyl)pyrazolo[1,5-a]pyrimidines. The structure of 3-bromo-2-methyl-5-phenyl-7-trifluoromethylpyrazolo[1,5-a]pyrimidine was established by X-ray diffraction analysis.

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Authors and Affiliations

  1. Ural Branch of the Russian Academy of Sciences, Institute of Organic Synthesis, 20 ul. S. Kovalevskoi, 620219, Ekaterinburg, Russian Federation

    V. I. Filyakova, O. A. Kuznetsova, M. I. Kodess & K. I. Pashkevich

  2. Ural State Technical University, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    E. N. Ulomskii & V. L. Rusinov

  3. Siberian Branch of the Russian Academy of Sciences, N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 9 prosp. Akad. Lavrent"eva, 630090, Novosibirsk, Russian Federation

    T. V. Rybalova & Yu. V. Gatilov

Authors
  1. V. I. Filyakova
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  2. O. A. Kuznetsova
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  3. E. N. Ulomskii
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  4. T. V. Rybalova
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  5. Yu. V. Gatilov
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  6. M. I. Kodess
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  7. V. L. Rusinov
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  8. K. I. Pashkevich
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Filyakova, V.I., Kuznetsova, O.A., Ulomskii, E.N. et al. Synthesis of (7-polyfluoroalkyl)pyrazolo[1,5-a]pyrimidines based on lithium fluorine-containing β-diketonates. Russian Chemical Bulletin 51, 332–336 (2002). https://doi.org/10.1023/A:1015420130033

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