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Giant Raman Scattering Spectra of the Molecular Complex Doxorubicin–DNA

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Journal of Applied Spectroscopy Aims and scope

Abstract

We have investigated the giant Raman scattering spectra of the doxorubicin–DNA complex adsorbed on the surface of annealed thin silver films modified by sodium chloride. It is found that doxorubicin interacts with DNA via carbon groups with involvement of their π‐electron system into interaction. Heating of a substrate in the process of adsorption from 20 to 37°C leads to a sharp increase in the number of chemisorbed molecules as a result of the thermally activated formation of specific adsorption sites. It has been found that in adsorption of the doxorubicin–DNA complex on the substrate surface, the chromophore molecules are oriented predominantly in parallel with the surface of the metal.

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Authors and Affiliations

  1. Ya. Kupala Grodno State University, 22 Ozheshko Str., Grodno, 230023, Belarus

    A. E. German, N. D. Strekal', S. A. Maskevich & G. A. Gachko

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  1. A. E. German
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  2. N. D. Strekal'
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  3. S. A. Maskevich
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  4. G. A. Gachko
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Correspondence to A. E. German.

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German, A.E., Strekal', N.D., Maskevich, S.A. et al. Giant Raman Scattering Spectra of the Molecular Complex Doxorubicin–DNA. Journal of Applied Spectroscopy 69, 28–32 (2002). https://doi.org/10.1023/A:1015399322821

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  • DOI: https://doi.org/10.1023/A:1015399322821

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