Skip to main content

Advertisement

SpringerLink
Log in

Serum Intercellular Adhesion Molecule-I in Children with Chronic Liver Disease: Relationship to Disease Activity

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

Intercellular adhesion molecule-I (ICAM-I) is a member of the immunoglobulin supergene family. It is expressed on the surface membrane of cells of multiple lineages at sites of inflammation. A soluble form of ICAM (sICAM-I) comprising the five extracellular Ig-like domains of ICAM-I has been detected in human serum and has been found to be increased in a variety of acute and chronic liver disorders. However, little is known about sICAM-I levels in children with chronic liver disease. Therefore, we measured sICAM-I in 23 children with chronic hepatitis, 14 children with cirrhosis, and 10 age- and sex-matched normal children by commercially available ELISA. We also correlated the sICAM-I levels with the histological activity index (HAI) score as determined from liver biopsies. Patients with chronic hepatitis had higher sICAM-I levels compared to controls (723 ± 272 ng/ml vs 282 ± 43 ng/ml, mean ± sd; P < 0.05). sICAM-I levels were also higher in patients with cirrhosis compared to controls (630 ± 218 ng, mean ± sd; P < 0.05). However, there was no significant difference between sICAM levels in patients with chronic hepatitis and cirrhosis. A significant correlation was found between the ICAM-I level and the histological activity index score in patients with chronic hepatitis (r = 0.58; P < 0.001) and in patients with cirrhosis (r = 0.7; P < 0.001). We also found that by using the cutoff level of 346 ng/ml, sICAM-I can be used as a screening test with high specificity (100%) and sensitivity (94%) to differentiate children with chronic liver disease from normal children. We conclude that sICAM is increased in children with chronic hepatitis and cirrhosis compared to controls. The degree of elevation correlates with the HAI score. sICAM may be used as a marker of the disease activity and may provide diagnostic and prognostic information in children with chronic liver disease. However, this needs to be further studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Springer TA: Adhesion receptors of the immune system. Nature 346:425–34, 1999

    Google Scholar 

  2. Nouri-Aria KT, Koskinas J, Portmann BC, Williams R: Serum intercellular adhesion molecule-I levels in chronic hepatitis C: Association with disease activity and response to interferon ? Gut 36:599–603, 1995

    PubMed  Google Scholar 

  3. Makgoba MW, Sanders ME, Luce GEG, et al: Functional evidence that ICAL-I is a ligand for LFA-I in cytotoxic T cell recognition. Eur J Immunol 18:637–640, 1988

    PubMed  Google Scholar 

  4. Van Seveneter GA, Shimizu Y, Horgan KJ, Shaw S: The LFA-I ligand ICAM-I provides an important costimulatory signal for T cell receptor-mediated activation of resting human T cell. J Immunol 144:4579–4586, 1990

    PubMed  Google Scholar 

  5. Rothelin R, Mainolfi EA, Czaikowski M, Marlin SD: A form of circulating ICAM-A in human serum. J Immunol 147:3788–3793, 1991

    PubMed  Google Scholar 

  6. Adams DH, Mainofli E, Burra P, et al: Detection of circulating intercellular adhesion molecule-I in chronic liver disease. Hepatology 16:810–814, 1992

    PubMed  Google Scholar 

  7. Kojima T, Sasai M, Kobayashi Y: Increased soluble ICAM-I in tracheal aspirates of infants with dysplasia. Lancet 342:1023–1024, 1993

    PubMed  Google Scholar 

  8. Knodell RG, Ishak KG, Balck WC, et al: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431–435, 1981

    PubMed  Google Scholar 

  9. Desmet VJ, Gerber M, Hoofnagle JH, et al: Classification of chronic hepatitis: Diagnosis, grading, and staging. Hepatology 19:1513–1520, 1994

    PubMed  Google Scholar 

  10. Simpson KJ, Hayes PC: Soluble adhesion molecules in immune mediated liver disease. Gut 36:806–808, 1995

    PubMed  Google Scholar 

  11. Lim AG, Jazraw RP, Ahmed HA, et al: Soluble intercellular adhesion molecule-I in primary biliary cirrhosis. Hepatology 20:882–888, 1994

    PubMed  Google Scholar 

  12. Bergasa NV, Newman W, Rothlein R, et al: Serum levels of soluble adhesion molecules (ICAM-I, V-CAM I and ESelectin) are markedly elevated in primary biliary cirrhosis (PBC) and unaffected by low dose oral methotrexate treatment. Gastroenterology 104:A877, 1993

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pediatrics, and Clinical Pathology, Mansoura University Children’s Hospital, Mansoura, Egypt

    Ahmed Abdalla, Abd-Al Gawad Sheesha, Mohammad Shokeir, Osama El-Agrody & Mohammad Ezz El-Regal

  2. Department of Pediatrics, Cairo University Children’s Hospital, Cairo, Egypt

    Mohammad K. Abdel-Khalik

  3. Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, New York, USA

    Katherine Freeman

  4. Department of Pediatrics, Upstate Medical University, Syracuse, New York, USA

    Anna Boneberg & Hassan H. A-Kader

Authors
  1. Ahmed Abdalla
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Abd-Al Gawad Sheesha
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohammad Shokeir
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Osama El-Agrody
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mohammad Ezz El-Regal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mohammad K. Abdel-Khalik
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Katherine Freeman
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Anna Boneberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hassan H. A-Kader
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abdalla, A., Sheesha, AA.G., Shokeir, M. et al. Serum Intercellular Adhesion Molecule-I in Children with Chronic Liver Disease: Relationship to Disease Activity. Dig Dis Sci 47, 1206–1208 (2002). https://doi.org/10.1023/A:1015393708187

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1015393708187

Search

Navigation