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Proteomic Code

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Abstract

On the basis of recent basic developments in protein structure, a proteomic code is suggested, which would potentially allow the sequence, structure, and function of proteins to be described by a spectrum of elementary loop-n-lock units. All major characteristics of the nearly standard units are described, and the first five “codons” of the proteomic code are presented with their respective unique sequences, structures, and functions. More such codons are to be discovered, and the general procedure for their identification is described.

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REFERENCES

  1. Trifonov, E.N., Bull. Math. Biol., 1989, vol. 51, pp. 417-432.

    Google Scholar 

  2. Trifonov, E.N., Encyclopedia of Molecular Biology, Creighton, T.E., Ed., New York-Toronto: John Wiley & Sons, 1999, pp. 2324-2326.

    Google Scholar 

  3. Branden, C. and Tooze, J., Introduction to Protein Structure, New York: Garland, 1999.

    Google Scholar 

  4. von Heijne, G., Eur. J. Biochem., 1983, vol. 133, pp. 17-21.

    Google Scholar 

  5. Varshavsky, A., Proc. Natl. Acad. Sci. USA, 1996, vol. 93, pp. 12142-12149.

    Google Scholar 

  6. Pietrokovski, S., Trends. Genet., 2001, vol. 17, pp. 465-472.

    Google Scholar 

  7. Henikoff, J.G., Greene, E.A., Pietrokovski, S., and Henikoff, S., Nucl. Acids Res., 2000, vol. 28, pp. 228-230.

    Google Scholar 

  8. Bairoch, A., Bucher, P., and Hofmann, K., Nucl. Acids Res., 1997, vol. 25, pp. 217-221.

    Google Scholar 

  9. Berezovsky, I.N., Namiot, V.A., Tumanyan, V.G., and Esipova, N.G., J. Biomol. Struct. Dyn., 1999, vol. 17, pp. 133-155.

    Google Scholar 

  10. Shimada, J. and Yamakawa, H., Macromolecules, 1984, vol. 17, pp. 689-698.

    Google Scholar 

  11. Yamakawa, H. and Stokmayer, W.H., J. Chem. Phys., 1972, vol. 57, pp. 2843-2854.

    Google Scholar 

  12. de Gennes, P.G., Introduction to Polymer Dynamics, Cambridge: Univ. Press, 1990.

    Google Scholar 

  13. Brant, D.A. and Flory, P.J., J. Amer. Chem. Soc., 1965, vol. 87, pp. 2788-2791.

    Google Scholar 

  14. Miller, W.G. and Goebel, C.V., Biochemistry, 1968, vol. 7, p. 3925.

    Google Scholar 

  15. Schimmel, P.R. and Flory, P.J., Proc. Natl. Acad. Sci. USA, 1967, vol. 58, pp. 52-59.

    Google Scholar 

  16. Miller, W.G., Brant, D.A., and Flory, P.J., J. Mol. Biol., 1967, vol. 23, pp. 67-80.

    Google Scholar 

  17. Berezovsky, I.N., Grosberg, A.Y., and Trifonov, E.N., FEBS Lett., 2000, vol. 466, pp. 283-286.

    Google Scholar 

  18. Berezovsky, I.N. and Trifonov, E.N., Prot. Engineering, 2001, vol. 14, pp. 403-407.

    Google Scholar 

  19. Hobohm, U. and Sander, C., Protein Science, 1994, vol. 3, pp. 522-524.

    Google Scholar 

  20. Lamarine, M., Mornon, J.-P., Berezovsky, I.N., and Chomilier, J., Cell. Mol. Life Sci., 2001, vol. 58, pp. 492-498.

    Google Scholar 

  21. Dokholyan, N.V. and Shakhnovich, E.I., J. Mol. Biol., 2001, vol. 312, pp. 289-307.

    Google Scholar 

  22. Qian, B. and Goldstein, R.A., Proteins, 2001, vol. 45, pp. 102-104.

    Google Scholar 

  23. Berezovsky, I.N. and Trifonov, E.N., J. Mol. Biol., 2001, vol. 307, pp. 1419-1426.

    Google Scholar 

  24. Berezovsky, I.N., Recent Research Developments in Protein Folding, Stability and Design, Gromiha, M.M. and Selvaraj, S., Eds., Trivandrum: Transworld Research Network (in press).

  25. Berezovsky, I.N. and Trifonov, E.N., Mol. Biol., 2001, vol. 35, pp. 233-239.

    Google Scholar 

  26. Trifonov, E.N., Kirzhner, A., Kirzhner, V.M., and Berezovsky, I.N., J. Mol. Evol., 2001, vol. 53, pp. 394-401.

    Google Scholar 

  27. Berezovsky, I.N., Kirzhner, A., Kirzhner, V.M., and Trifonov, E.N., Proteins: Structure, Function, and Genetics, 2001 (in press).

  28. Pace, C.N., Horn, G., Hebert, E.J., Bechert, J., Shaw, K., Urbanikova, L., Scholtz, J.M., and Sevcik, J., J. Mol. Biol., 2001, vol. 312, pp. 393-404.

    Google Scholar 

  29. Levitt, M. and Chothia, C., Nature, 1976, vol. 261, pp. 552-558.

    Google Scholar 

  30. Linial, M., Linial, N., Tishby, N., and Yona, G., J. Mol. Biol., 1997, vol. 268, pp. 539-556.

    Google Scholar 

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Trifonov, E.N., Berezovsky, I.N. Proteomic Code. Molecular Biology 36, 239–243 (2002). https://doi.org/10.1023/A:1015326124039

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