Abstract
Plasmid vaccine pBK-CMVMP1LC113 expressing the matrix (M) gene of rinderpest virus was assessed for its potential to protect rabbits against a lethal viral challenge. Rabbits immunized with plasmids expressing the M gene were not protected when challenged with lapinized rinderpest virus, despite the production of anti-M antibodies, while rabbits immunized with rinderpest tissue culture vaccine were completely protected from a lethal challenge with lapinized rinderpest virus. The plasmid vaccine also had no significant effect on the lymphopenia in challenged rabbits. The results indicate that rinderpest M protein does not have a protective role in rinderpest infection.
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Pahar, B., Sharma, B. & Goel, A. Effect of Immunization with Plasmid DNA Encoding for Rinderpest Virus Matrix Protein on Systemic Rinderpest Virus Infection in Rabbits. Vet Res Commun 26, 227–237 (2002). https://doi.org/10.1023/A:1015257721988
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DOI: https://doi.org/10.1023/A:1015257721988