Abstract
Exposure of amino acids, peptides and proteins to radicals in the presence of O2generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO•), peroxyl (ROO•) and carbon-centred (R•) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.
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Luxford, C., Dean, R.T. & Davies, M.J. Induction of DNA damage by oxidised amino acids and proteins. Biogerontology 3, 95–102 (2002). https://doi.org/10.1023/A:1015228001561
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DOI: https://doi.org/10.1023/A:1015228001561