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Relationship between mercury concentration in blood, cognitive performance, and blood pressure, in an elderly urban population

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Abstract

Concentration of mercury (Hg) in whole blood in an elderly urban population with a mean age of 87 years was studied in relation to cognitive function, arterial blood pressure (arterial BP), age, gender, body mass index (BMI) and smoking habits. This population-based study consisted of 106 subjects both males and females. Clinical assessment of the subjects included medical and social history, physical and neurologic examination and assessment of cognitive functions with Mini-Mental State Examination (MMSE). Information on use of all potentially anti-hypertensive drugs was collected. Whole blood from 106 subjects were collected and analysed for mercury by Cold Vapour Atomic Absorption Spectrometry (Milton Ray ASS-CV) with Seronorm Trace Element as matrix matched quality control. Males and females did not differ in blood-mercury (B-Hg) concentrations or in any of the other studied variables. B-Hg concentrations did not differ between smokers and non-smokers. Females were treated more often than males with antihypertensive drugs. There was no relation found between B-Hg concentration and cognitive function, arterial BP, age, gender or BMI. In conclusion, no relations were found between B-Hg concentrations and the studied variables.

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References

  • Aberg B, Ekman L, Falk R, Greitz U, Persson G, Snihs JO. 1969 Metabolism of Methylmercury (203Hg ) compounds in man. Arch Environ Health 19, 478-484.

    Google Scholar 

  • Basun H, Forsell GL, Wetterberg L, Winblad B. 1991 Metals and trace elements in plasma and cerebrospinal fluid in normal ageing and Alzheimer's disease. J Neural Transm 4, 231-258.

    Google Scholar 

  • Basun H, Lind B, Nordberg M, Nordström M, Sparring-Bjorksten K, Winblad B. 1994 Cadmium in blood in Alzheimer's disease and non-demented subjects. Biometals 7, 130-134.

    Google Scholar 

  • Birke G, Johnels AG, Plantin L-O, Sjostrand, Skerfving S, Westermark T. 1972 Studies on humans exposed to methyl mercury through fish consumption. Arch Environ Health 25, 77-91.

    Google Scholar 

  • Clarkson TW. 1997 The toxicology of mercury. Crit Rev Clin Labo Sci 34(4), 369-403.

    Google Scholar 

  • Davidson PW, Myers GJ, Cox C et al. 1995 Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicol. 16(4), 677-688.

    Google Scholar 

  • Davidson PW, Myers GJ, Cox C et al. 1998 Effects of prenatal and postnatal methylmercury exposure from fish comsumption on neurodevolepment: Outcomes at 66 months of age in the Seychelles Child Development Study. JAMA 280(8), 701-707.

    Google Scholar 

  • Ehmann WD, Markesbery WR, Alauddin M, Hossian TIM, Brubaker EH. 1986 Brain trace elements in Alzheimer's disease. Neurotoxicol. 7(1), 197-206.

    Google Scholar 

  • Folstein MF, Folstein SE, Mc Hugh PR. 1975 'Mini-Mental State': A practical method for grading the cognitive state of patients for the clinican. J Psychiatr Res 12, 189.

    Google Scholar 

  • Fratiglioni L, Grut M, Forsell Y et al. 1991 Prevalence of Alzheimer's disease and other dementias in an elderly population: Relationship with age, sex, and education. Neurology 41, 1886-1892.

    Google Scholar 

  • Fratiglioni L, Viitanen M, Bäckman L, Sandman PO, Winblad B. 1992 Occurrence of Dementia in Advanced Age: The Study Design of the Kungsholmen Project. Neuroepidemiology 11 (suppl 1), 29-30.

    Google Scholar 

  • Grandjean P, Weihe P, White RF et al. 1997 Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol 19(6), 417-428.

    Google Scholar 

  • Grandjean P, Weihe P, White RF et al. 1998 Prenatal exposure to methylmercury in the Faroe Islands and neurobehavioural performans at age seven years. Response to workgroup questions for presentation on 18-20 Nov. 1998. In: Scientific Issues Relevant to Assessment of Health Effects from Exposure to Methylmercury Appendix II-B, Faraoe Islands Studies. National Institute for Environmental Health Sciences. Available: http//ntpserver.niehs.nih.gov/main_pages/PUBS/MethMercWshpRpt.html.

  • Grandjean P, Budtz-Jorgensen E, White RF, Weihe P, Debes F, Keiding N. 1999 Methylmercury exposure biomarkers as indicators of neurotoxicity in children age 7 years. Am J Epidemiol 150(3), 301-305.

    Google Scholar 

  • Hock C, Drasch G, Golombowski S et al. 1998 Increased blood mercury levels in patients with Alzheimer's disease. J Neural Transm 105, 59-68.

    Google Scholar 

  • Kjellstrom T, Kennedy P, Wallis S, Mantell C. 1986 Physical and mental development of children with prenatal exposure to mercury from fish. National Swedish Environmental Protection Board report 3080, Stockholm, Sweden.

  • Kjellstrom T, Kennedy P, Wallis S. et al. 1989 Physical and Mental Development of children with Prenatal Exposure to Mercury from Fish. Stage II: Interviews and psychological tests at age 6. National Swedish Environmental Protection Board report 3080, Stockholm, Sweden.

  • Miettinen JK. 1973 Absorption and elimination of dietary (Hg++) and methylmercury in man. In: Mercury, Mercurial and Mercaptans, MW Miller, and TW Clarkson, eds. Springfield, IL: CC Thomas; 233-246.

    Google Scholar 

  • Nordberg M, Winblad B, Fratiglioni L, Basun H. 2000a Lead Concentrations in Elderly Urban People Related to Blood Pressure and Mental Performance: Results From a Population Based Study. Am J Industr Med 38, 290-294.

    Google Scholar 

  • Nordberg M, Winblad B, Basun H. 2000b Cadmium concentration in Blood in An Elderly Urban Population. BioMetals 13, 311-317.

    Google Scholar 

  • NRC. 2000 National Research Council. Toxicological Effects of Methylmercury. Washington DC: National Academy Press; 43-46.

    Google Scholar 

  • Office of Technology Assessment. Neurotoxicity. 1990 Identifying and controlling Poisons of the Nervous System. Washington DC: U.S. Government Printing Office.

    Google Scholar 

  • Rice DC. 1996 Evidence for delayed neurotoxicity produced by methylmercury. Neurotoxicol 17, 583-596.

    Google Scholar 

  • Rice DC and Hayward S. 1999 Comparison of Visual Function at Adulthood and During Ageing in Monkeys Exposed to Lead or Methylmercury. Neurotoxicol 20(5), 767-784.

    Google Scholar 

  • Scherlock J, Hislop J, Newton D, Topping G, Whittle K. 1984 Elevation of mercury in human blood from controlled chronic ingestion of methylmercury in fish. Hum Toxicol 3, 117-131.

    Google Scholar 

  • Steuerwald U, Weihe P, Jorgensen PJ et al. 2000 Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr 136(5), 571-573; 599-605.

    Google Scholar 

  • Tsubaki T, Irukayama K. 1977 Minamata Disease. Amsterdam: Elsevier.

    Google Scholar 

  • Thompson CM, Markesbery WR, Ehmann WD, Mao YX, Vance DE. 1988 Regional brain trace element studies in Alzheimer's disease. Neurotoxicol 9, 1-8.

    Google Scholar 

  • Weiss B, Simon W. 1975 Quantitative perspectives on the long-term toxicity of methylmercury and similar poisons. In: Weiss B, Simon W, eds. Behavioural Toxicology New York: Plenum Press; 429-438.

    Google Scholar 

  • Weiss B. 1990 Risk assessment: the insidious nature of neurotoxicity and the ageing brain. Neurotoxicol 11, 305-31

    Google Scholar 

  • WHO/IPCS. 1989 Mercury: Environmental Aspects, Environmental Health Criteria 86, IPCS, World Health Organisation, Geneva.

    Google Scholar 

  • WHO/IPCS. 1990 Methylmercury: Environmental Aspects, Environmental Health Criteria 101, IPCS, World Health Organisation, Geneva.

    Google Scholar 

  • WHO/IPCS. 1991 Inorganic Mercury: Environmental Aspects, Environmental Health Criteria 118, IPCS, World Health Organisation, Geneva.

    Google Scholar 

  • WHO/IPCS. 1993 Principles for Evaluating Chemical Effects on the Aged Population. Environmental Health Criteria 144, IPCS, World Health Organisation, Geneva.

    Google Scholar 

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Johansson, N., Basun, H., Winblad, B. et al. Relationship between mercury concentration in blood, cognitive performance, and blood pressure, in an elderly urban population. Biometals 15, 189–195 (2002). https://doi.org/10.1023/A:1015202301127

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