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Local Regulation of Proliferation and Differentiation of Hemopoietic Precursors during Experimental Neuroses

Bulletin of Experimental Biology and Medicine volume 133, pages 12–16 (2002)Cite this article

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Abstract

Intensive formation of hemopoietic islets and secretion of humoral hemopoiesis stimulators by cells of the hemopoietic microenvironment underlie activation of proliferation and differentiation of erythroid and granulocyte-macrophage precursors in conflict situation. Stimulation of division and maturation of committed granulomonocytic precursors during paradoxical sleep deprivation is primarily related to intensive secretion of humoral factors by hemopoietic elements. The inhibition of proliferative activity and differentiation of erythroid precursors is associated with the impaired formation of erythroid hemopoietic islets and suppressed secretion of humoral erythropoiesis stimulators by nonadherent fractions of the hemopoietic microenvironment.

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REFERENCES

  1. E. D. Gol.berg, A. M. Dygai, and V. P. Shakhov, Tissue Cultures in Hematology [in Russian], Tomsk (1992).

  2. E. D. Gol'dberg, A. M. Dygai, E. G. Skurikhin, et al., Byull. Eksp. Biol. Med., 129, No. 4, 381-385 (2000).

    Google Scholar 

  3. E. D. Gol.berg, A. M. Dygai, N. I. Suslov, et al., Byull. Sib. Otd. Ros. Akad. Med. Nauk, No. 1, 129-134 (1998).

  4. E. D. Gol'dberg, A. M. Dygai, and E. Yu. Sherstoboev, Mechanisms of Local Regulation of Hemopoiesis [in Russian], Tomsk (2000), p. 148.

  5. A. M. Dygai, E. G. Skurikhin, N. I. Suslov, et al., Byull. Eksp. Biol. Med., 126, No. 12, 628-631 (1998).

    Google Scholar 

  6. A. M. Dygai, N. I. Suslov, E. G. Skurikhin, and A. A. Churin, Ibid., 123, No. 2, 158-161 (1997).

    Google Scholar 

  7. T. A. Klygul. and N. A. Krivopalov, Farmakol. Toksikol., No. 2, 241-244 (1966).

  8. N. V. Provalova, Adrenergic Structures of the Nervous System in the Regulation of Hemopoiesis during Experimental Neuroses, Abstract of Cand. Med. Sci. Dissertation, Tomsk (1999).

  9. E. G. Skurikhin, A. M. Dygai, N. I. Suslov, et al., Byull. Eksp. Biol. Med., 131, No. 1, 43-47 (2001).

    Google Scholar 

  10. E. G. Skurikhin, N. I. Suslov, N. V. Provalova, et al., Ibid., 127, Suppl. 1, 7-11 (1999).

    Google Scholar 

  11. K. V. Sudakov, General Theory of Functional Systems [in Russian], Moscow (1984), p. 224.

  12. Emotional Stress: Theoretical and Practical Aspects, Eds. K. V. Sudakov and V. I. Petrov [in Russian], Volgograd (1997), p. 168.

  13. P. R. Crocker and S. Gordon, J. Exp. Med., 31, 43-50 (1985).

    Google Scholar 

  14. M. Thakkar and B. N. Mallick, Sleep, 16, No. 8, 691-694 (1993).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Pathological Physiology and Experimental Therapy, Group of Psychopharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, Tomsk

    A. M. Dygai, E. G. Skurikhin, N. V. Provalova & N. I. Suslov

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  1. A. M. Dygai
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  2. E. G. Skurikhin
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  3. N. V. Provalova
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  4. N. I. Suslov
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Dygai, A.M., Skurikhin, E.G., Provalova, N.V. et al. Local Regulation of Proliferation and Differentiation of Hemopoietic Precursors during Experimental Neuroses. Bulletin of Experimental Biology and Medicine 133, 12–16 (2002). https://doi.org/10.1023/A:1015179721834

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  • DOI: https://doi.org/10.1023/A:1015179721834

  • experimental neuroses
  • hemopoietic precursors
  • hemopoietic islets
  • hemopoiesis-inducing microenvironment