Abstract
A method is presented for modeling the effect of two stresses on mortality. The model assumes a multiplicative simple two-parameter dose-response curve relationship between mortality and the two factors as well as for the effect of combining the two factors. The dose-response curve is modified in order to model survival probabilities. It is shown that the model adequately describes mortality data of Folsomia candida (Collembola) in a two-stress factor design.
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References
Bliss, C.I. (1939) The toxicity of poisons applied jointly. Ann. Appl. Biol., 26, 585–615.
Greco, W., Unkelbach, H.-D., Pöch, G., Sühnel, J., Kundi, M., and Bödeker, W. (1992) Consensus on concepts and terminology for combined-action assessment: The Saariselkä agreement. ACES, 4, 65–9.
Haanstra, L., Doelman, P., and Oude Voshaar, J.H. (1985) The use of sigmoidal dose response curves in soil ecotoxicological research. Plant & Soil, 84, 293–7.
Hojer, R., Bayley, M., Damgaard, C., and Holmstrup, M. (2001) Stress synergy between a common environmental contaminant and drought. Global Change Biology, 7, 485–494
Holmstrup, M. (1997) Drought tolerance in Folsomia candida Willem (Collembola) after exposure to sublethal concentrations of three soil-polluting chemicals. Pedobiologia, 41, 361–8.
Jagers op Akkerhuis, G.A.J.M., Kjaer, C., Damgaard, C., and Elmegaard, N. (1999) Temperature-dependent, time-dose-effect model for pesticide effects on growing, herbivorous Arthropods: Bioassays with Dimethoate and Cypermethrin. Environmental Toxicology and Chemistry, 18, 2370–8.
Klepper, O. and Bedaux, J.J.M. (1997) Nonlinear parameter estimation for toxicological threshold models. Ecological modeling, 102, 315–24.
Kooijman, S.A.L.M. and Bedaux, J.J.M. (1996) The Analysis of Aquatic Toxicity Data, VU University Press, Amsterdam.
Logan, D.T. and Wilson, H.T. (1995) An ecological risk assessment method for species exposed to contaminant mixtures. Environmental Toxicology and Chemistry, 14, 351–9.
PapeLindstrom, P.A. and Lydy, M.J. (1997) Synergistic toxicity of atrazine and organophosphate contravenes the response addition mixture model. Environmental Toxicology and Chemistry, 16, 2415–20.
Sprague, J.B. (1970) Measurement of pollutant toxicity to fish: II. Utilizing and applying bioassay approach. Water Research, 4, 3–32.
Walker, C.H., Hopkin, S.P., Sibly, R.M., and Peakall, D.B. (1996) Principles of Ecotoxicology, Taylor & Francis, London.
Wolfram, S. (1999) The Mathematica Book, Cambridge University Press, Cambridge.
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Damgaard, C., Hojer, R., Bayley, M. et al. Dose-response curve modeling of excess mortality caused by two forms of stress . Environmental and Ecological Statistics 9, 195–200 (2002). https://doi.org/10.1023/A:1015174205385
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DOI: https://doi.org/10.1023/A:1015174205385