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Effect of Myelopeptide-2 on the Development of Spontaneous and Urethane-Induced Tumors in Mice

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Abstract

We studied the effect of endogenous immunoregulatory myelopeptide-2 on the development of spontaneous and urethane-induced lung adenomas. Long-term treatment with myelopeptide-2 (25 injections) in parallel with urethane poisoning decreased animal mortality caused by this carcinogen. Short-term treatment with myelopeptide-2 decreased the number of spontaneous and urethane-induced lung tumors in mice. Myelopeptide-2 delayed the appearance of urethane-induced tumors irrespective of the number of injections.

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Authors and Affiliations

  1. M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia

    A. A. Mikhailova, E. A. Kirilina, O. V. Morozova & V. S. Turusov

  2. Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    A. A. Mikhailova, E. A. Kirilina, O. V. Morozova & V. S. Turusov

Authors
  1. A. A. Mikhailova
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  2. E. A. Kirilina
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  3. O. V. Morozova
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  4. V. S. Turusov
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Mikhailova, A.A., Kirilina, E.A., Morozova, O.V. et al. Effect of Myelopeptide-2 on the Development of Spontaneous and Urethane-Induced Tumors in Mice. Bulletin of Experimental Biology and Medicine 133, 68–70 (2002). https://doi.org/10.1023/A:1015164713174

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  • DOI: https://doi.org/10.1023/A:1015164713174

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