Cancer Causes & Control

, Volume 13, Issue 3, pp 287–293 | Cite as

Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States)

  • Manuela Gago-Dominguez
  • J. Esteban Castelao
  • Jian-Min Yuan
  • Ronald K. Ross
  • Mimi C. Yu


Multiple studies have noted that obese individuals are at a high risk of renal cell cancer. Similarly, numerous case–control and cohort studies have consistently reported that individuals with a history of hypertension experience an increased risk of renal cancer. In spite of this compelling body of epidemiologic data, no credible hypothesis has been advanced to explain this dual etiologic association. In this communication we propose that lipid peroxidation, which is increased in obese and hypertensive subjects, is the mechanism responsible, at least in part, for their increased risk of renal cell carcinoma. In experimental animals lipid peroxidation of the proximal renal tubules is a necessary mechanistic pathway in renal carcinogenesis induced by several different chemicals. Our hypothesis may also explain the roles of other risk (oophorectomy/hysterectomy, parity, smoking, diabetes) and protective factors (dietary antioxidants) for renal cell cancer.

hypertension lipid peroxidation obesity oophorectomy parity renal cell cancer smoking 


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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Manuela Gago-Dominguez
    • 1
  • J. Esteban Castelao
    • 1
  • Jian-Min Yuan
    • 1
  • Ronald K. Ross
    • 1
  • Mimi C. Yu
    • 1
  1. 1.Department of Preventive Medicine, USC/Norris Comprehensive Cancer CenterUniversity of Southern CaliforniaLos AngelesUSA

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