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A calorimetric investigation into copper–arginine and copper–alanine solid state interactions


Complexes of formula CuCl2 · 2arg and CuCl2 · 4ala (arg = arginine; ala = alanine) were prepared at room temperature by a solid state route. The metal–amino acid solid state interactions were studied by i.r. spectroscopy and solution calorimetry. For both complexes, participation of the carboxylate group as well as nitrogen in coordination are inferred, based on the i.r. data. For the copper–arginine compound, the calculated thermochemical parameters are: ΔrHm θ = −114.9 ± 1.42 and ΔfHm θ = −1608.3 ± 11.6 kJ mol−1. For copper–alanine compound, a complete set of thermochemical parameters were calculated: ΔrHm θ = −18.0 ± 0.9; ΔfHm θ = −2490.4 ± 4.3; ΔDHm θ = 597.2 ± 17.7; ΔMHm θ = 771.9 ± 18.7; ΔgHm θ = 627.1 ± 22.3 and 〈D〉 (Cu−L) = 156.8 ± 5.7 kJ mol−1. Based on ΔrHm θ and dissolution enthalpy values, a stronger intermolecular solid state interaction can be inferred for the arginine complex, than for the alanine one complex, probably due to the formation of intermolecular hydrogen bonds in the former.

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  1. R.H. Garret and C.M. Grisham, Biochemistry, Saunders, New York, 1995.

    Google Scholar 

  2. J.J.R.F. da Silva and R.J.P. Williams, The Biological Chemistry of the Elements, Oxford University Press, London, 1991.

    Google Scholar 

  3. R.F. de Farias, J. Scatena Jr. and C. Airoldi, J. Inorg. Biochem., 73, 253 (1999).

    Google Scholar 

  4. R.F. de Farias and C. Airoldi, J. Inorg. Biochem., 76, 273 (1999).

    Google Scholar 

  5. R.F. de Farias, L.M. Nunes and C. Airoldi, J. Thermal Anal. Cal., accepted for publication.

  6. R.F. de Farias, O.A. de Oliveira, J.V. de Medeiros and C. Airoldi, Thermochim. Acta, 328, 241 (1999).

    Google Scholar 

  7. R.F. de Farias, G.C. Petrucelli and C. Airoldi, Thermochim. Acta, accepted for publication.

  8. R.F. de Farias and L.M. Nunes, Transition Met. Chem., in press.

  9. K. Nakamoto, Infrared and Raman Spectra of Inorganic and Coordination Compounds, 4th edit., Wiley, New York, 1986.

    Google Scholar 

  10. P. Melnikov, P.P. Corbi, C.D. Aguila, M.A. Zacharias, M. Cavicchioli and A.C. Massabni, J. Alloys Comp., 307, 179 (2000).

    Google Scholar 

  11. CRC Handbook of Chemistry and Physicis, 79th edit., CRC Press, 1998.

  12. J.B. Pedley, R.D. Muylor and S.P. Kirby, Thermochemical Data of Organic Compounds, 2nd edit., Chapman and Hall, London, 1992.

    Google Scholar 

  13. S.N. Ngauv, R. Sabbah and M. Laffite, Thermochim. Acta, 20, 371 (1997).

    Google Scholar 

  14. X.W. Yang, J.R. Liu, S.L. Gao, Y.D. Hou and Q.Z. Shi, Thermochim. Acta, 329, 109 (1999).

    Google Scholar 

  15. R.F. de Farias and O.A. de Oliveira, Quím. Nova, 19, 100 (1996).

    Google Scholar 

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de Farias, R.F., Martínez, L. & Airoldi, C. A calorimetric investigation into copper–arginine and copper–alanine solid state interactions. Transition Metal Chemistry 27, 253–255 (2002).

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  • Hydrogen
  • Copper
  • Enthalpy
  • Hydrogen Bond
  • Carboxylate