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Ascorbic Acid Supplement During Luteal Phase in IVF

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Abstract

Purpose: To evaluate the impact of ascorbic acid of different doses as additional support during luteal phase in infertility treatment by means of a prospective, randomized, placebo-controlled, group comparative, double-blind study. Methods: Voluntary daily oral intake of either ascorbic acid (1, 5, or 10 g/day) or Placebo for 14 days after follicle aspiration for IVF-ET procedure. Data was obtained on 620 cases of women, age <40 years, undergoing first IVF-embryo transfer cycles in two private out-patient infertility clinics. All women were stimulated by the same protocol. The mean age was 31.73 (±4.4 SD) years. Results: No differences in clinical pregnancy rate and implantation rate were noted in statistical logistic regression analysis between the four intake groups. Conclusions: There was no clinical evidence of any beneficial effect, as defined by main outcome measures, of ascorbic acid on IVF-ET. Our data suggest there is no obvious value of high dosed intake of vitamin C during luteal phase in infertility treatment.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Vienna, Waehringer Guertel, Vienna, Austria

    Georg Griesinger

  2. Institut fuer Sterilitaetsbetreuung, Lainzerstrasse, Vienna, Austria

    Georg Griesinger, Katharina Franke, Cordelia Kinast, Alexandra Kutzelnigg, Sandra Riedinger & Wilfried Feichtinger

  3. Kaali Intezet, Isztenhegy ut 54a, Budapest, Hungary

    Sandor Kulin & Steven G. Kaali

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  1. Georg Griesinger
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  2. Katharina Franke
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  3. Cordelia Kinast
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  4. Alexandra Kutzelnigg
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  5. Sandra Riedinger
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  6. Sandor Kulin
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  7. Steven G. Kaali
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  8. Wilfried Feichtinger
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Correspondence to Wilfried Feichtinger.

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Griesinger, G., Franke, K., Kinast, C. et al. Ascorbic Acid Supplement During Luteal Phase in IVF. J Assist Reprod Genet 19, 164–168 (2002). https://doi.org/10.1023/A:1014837811353

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