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Chemical Modification of Plant Alkaloids. 2. Reaction of Cotarnine with Barbituric Acid Derivatives and Structure of 5-Dihydrocotarnylbarbituric Acids

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Abstract

The reaction of barbituric acid and its N-substituted derivatives and 2-thio analogs with cotarnine forms 5-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-2H-1,3-methylenedioxy-[4,5-g]isoquinolinyl-1)barbituric acids, a new class of zwitter-ions, the structure of which was studied by 1 H and 13 C NMR spectroscopy and mass spectrometry. The prepared compounds exist in solution as stable intermolecular associates and have a complicated H-bonded structure.

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Authors and Affiliations

  1. I. I. Mechnikov St. Petersburg State Medical Academy, 195067, St. Petersburg, Piskarevskii pr., 47

    K. A. Krasnov & M. N. Yurova

  2. ZAO "InterBioScreen,", 142432, Chernogolovka, Moscow District, Institutskii pr., 8

    V. G. Kartsev

Authors
  1. K. A. Krasnov
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  2. V. G. Kartsev
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  3. M. N. Yurova
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Krasnov, K.A., Kartsev, V.G. & Yurova, M.N. Chemical Modification of Plant Alkaloids. 2. Reaction of Cotarnine with Barbituric Acid Derivatives and Structure of 5-Dihydrocotarnylbarbituric Acids. Chemistry of Natural Compounds 37, 543–550 (2001). https://doi.org/10.1023/A:1014821016904

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