Abstract
Animal studies of the topical application of adenosine A 2A receptor agonists show that it promotes wound closure. To further confirm the efficacy of adenosine A 2A receptor agonists as promoters of wound healing, we compared the effect of MRE0094, a novel selective adenosine A 2A receptor agonist, to CGS-21680, a reference selective adenosine A 2A receptor agonist, as well as to recombinant human platelet–derived growth factor (0.01% Becaplermin gel), an agent currently used to promote healing of diabetic ulcers, on wound closure in healthy BALB/C mice. Wounds (∼12 mm diameter) were created on the dorsum of mice (two per mouse) and then treated daily with vehicle, 0.01% Becaplermin gel, or different doses of the adenosine A 2A receptor agonists. The wound margins were traced onto plastic sheets, and the wound areas were digitized, quantitated, and compared. We found that application of MRE0094 (1 μg/wound and 10 μg/wound) and CGS-21680 (1 μg/wound and 5 μg/wound) achieved 50% wound closure significantly more rapidly than control application (day 1.9, 1.9, 3.5, 3.2, respectively, versus control day 4, p < 0.05 ANOVA). Surprisingly, neither higher nor lower concentrations of CGS-21680 affected the rate of wound closure, as compared to control. In contrast, Becaplermin gel did not increase the rate at which wounds closed (50% closure by day 7.2, p = NS versus control). These data confirm our prior observations that adenosine A 2A receptor agonists promote wound closure, and they suggest that these agents may be as effective if not more effective than Becaplermin gel for the treatment of poorly healing wounds.
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Victor-Vega, C., Desai, A., Montesinos, M.C. et al. Adenosine A2A Receptor Agonists Promote More Rapid Wound Healing Than Recombinant Human Platelet–Derived Growth Factor (Becaplermin Gel). Inflammation 26, 19–24 (2002). https://doi.org/10.1023/A:1014417728325
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DOI: https://doi.org/10.1023/A:1014417728325