International Urology and Nephrology

, Volume 32, Issue 4, pp 525–530 | Cite as

Wild garlic has a greater effect than regular garlic on blood pressure and blood chemistries of rats

  • Harry G. Preuss
  • Dallas Clouatre
  • Ali Mohamadi
  • S. Taylor Jarrell


When groups of 10 Spontaneously Hypertensive Rats (SHR) were fed diets containing either 1% w/w regular garlic (Allium sativum) (AS) or 1% w/w wild garlic (Allium ursinum) (AU) for 45days, the final mean systolic blood pressure (SBP) was reduced significantly compared to control (C) (C 189; AS 175; Au 173 mm Hg). Compared to C, body weight and circulating glucose and triglyceride levels were not significantly different; but circulating insulin was significantly higher (C 23.6; AS33.9; AU 29.5 uIU/dl), and total cholesterol was significantly lower (C 133; AS 115; AU117 mg/dl) in the two groups consuming AS or AU. HDL rose in the two garlic groups, but the differences from C were statistically significant only for the AU group. In a second study, the effects of a lower dose of dietary AS and AU (0.1% w/w) on SBP and various blood chemistries were compared head-to-head in 80SHR — 40 control and 40 test rats. Both AS and AU decreased SBP significantly compared to a control group of 10 SHR followed simultaneously. However, AU at this lower concentration produced a significantly greater SBP-lowering effect compared to the AS group. In addition, AU decreased total cholesterol significantly and tended to increase HDL compared to AS. Accordingly, the results suggest that AU has a greater therapeutic benefit compared to AS at a given concentration.

Bear's garlic Cardiovascular effects Blood pressure Effects of garlic Garlic - Cultivated Wild (Bear's) Wild garlic cardiovascular effects 


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  1. 1.
    Chopra RN, Chopra IC, Handa KL, Kapur LD. Indigenous Drugs of India, Allium sativum, Second Edition. Calcutta: Dhru and Sons, 1951, p. 251.Google Scholar
  2. 2.
    Kendler BS. Garlic (Allium sativum) and Onion (Allium cepa): a review of their relationship to cardiovascular disease. Preventive Med 1987; 16: 670–685.CrossRefGoogle Scholar
  3. 3.
    Knipschild KP, Ter Riet G. Garlic, onions and cardiovascular risk factors. A review of the evidence from human experiments with emphasis on commercially available preparations. Br. J Clin Pharmac 1989; 28: 535–544.Google Scholar
  4. 4.
    Murray MT. Cardiovascular effects of commercial garlic preparations. Am J Nat Med 1995; 2: 5–7.Google Scholar
  5. 5.
    Dausch JG, Nixon DW. Garlic: a review of its relationship to malignant disease. Prev Med 1990; 19: 346–361.PubMedCrossRefGoogle Scholar
  6. 6.
    Han J. Highlights of the cancer chemoprevention studies in China. Prev Med 1993; 22: 712–722.PubMedCrossRefGoogle Scholar
  7. 7.
    Lerner DJ, Hulley SB. Does eating garlic lower cholesterol? Ann Intern Med (letter) 1994; 120: 969.Google Scholar
  8. 8.
    Harenberg J, Giese C, Zimmerman R. Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemia. Atherosclerosis 1988; 74: 247–249.PubMedCrossRefGoogle Scholar
  9. 9.
    Chi MS, Koh ET, Stewart TJ. Effects of garlic on lipid metabolism in rats fed cholesterol or lard. J Nutr 1982; 112: 241–248.PubMedGoogle Scholar
  10. 10.
    Silagy C, Neil A. Garlic as a lipid lowering agent - a meta analysis. J Roy Coll Physic 1994; 28: 39–45.Google Scholar
  11. 11.
    Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids 1994; 29: 189–193.PubMedGoogle Scholar
  12. 12.
    Heinle H, Betz E. Effects of dietary garlic supplementation in a rat model of atherosclerosis. Drug Res 1994; 44: 614–617.Google Scholar
  13. 13.
    Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J of Clin Pharmacol, Therapy and Toxicology. 1991; 29: 151–155.Google Scholar
  14. 14.
    Mansell P, Reckless JPD. Effects on serum lipids, blood pressure, coagulation, platelet aggregation, and vasodilation. Br Med J 1991; 303: 379–380.CrossRefGoogle Scholar
  15. 15.
    Kiesewetter H, Jung F, Mrowietz C, Koscielny J, Wenzel E. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol 1993; 45: 333–336.PubMedCrossRefGoogle Scholar
  16. 16.
    Chang MLW, Johnson MA. Effect of garlic on carbohydrate metabolism and lipid synthesis in rats. J Nutr 1980; 110: 931–936.PubMedGoogle Scholar
  17. 17.
    Ernst E. Cardiovascular effects of garlic (Allium sativum): a review. Pharmacotherapeutica 1987; 5: 83–89.Google Scholar
  18. 18.
    Auer W, Eiber A, Hertkorn E, Hoehfeld E, Koihrle U, Lorenz A, Mader F, Merx W, Otto G, Schmid-Otto B, Taubenheim H. Hypertension and hyperlipidaemia: garlic helps in mild cases. Br J Clin Prac 1990; 69: 3–6.Google Scholar
  19. 19.
    McMahon FG, Vargas R. Can garlic lower blood pressure? A pilot study. Pharmacotherapy 1993; 13: 406–407.PubMedGoogle Scholar
  20. 20.
    Clouatre D. European Wild Garlic. The Better Garlic. San Francisco CA: Pax Publishing, 1995, pp. 1–38.Google Scholar
  21. 21.
    Chandorkar AG, Jain PK. Analysis of hypotensive action of Allium sativum (Garlic). Ind J Physiol Pharmac 1973; 17: 132–133.Google Scholar
  22. 22.
    Banerjee AK. Effect of aqueous extract of garlic on arterial blood pressure of normotensive and hypertensive rats. Artery 1976; 2: 369–373.Google Scholar
  23. 23.
    Reuter HD, Sendl A. Allium sativum and Allium ursinum: Chemistry, pharmacology and medicinal applications. Economic and Medicinal Plant Research 1994; 6: 55–113.Google Scholar
  24. 24.
    Mutsch-Eckner M, Meier B, Wright AD, Sticher O. Gammaglutamyl peptides from allium sativum bulbs. Phytochemistry 1992; 31: 2389–2391.CrossRefGoogle Scholar
  25. 25.
    Meunier MT, Villie F, Jonadet M, Bastide J, Bastide P. Inhibition of angiotensin I converting enzyme by flavianolic compounds: in vitro and in vivo studies. Planta medica 1986; 53: 12–15.CrossRefGoogle Scholar
  26. 26.
    Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Plant Medica 1992; 58: 1–7.Google Scholar
  27. 27.
    Wagner H, Elbl G, Lotter H, Guinea M. Evaluation of natural products as inhibitors of angiotension I - converting enzyme (ACE). Pharmacol Lett 1991; 1: 15–18.Google Scholar
  28. 28.
    Rietz B, Isensee H, Strobach H, Makdessi S, Jacob R. Cardioprotective actions of wild garlic (Allium ursinum) in ischemia and reperfusion. Mol Cell Biochem 1993; 119: 143–150.PubMedCrossRefGoogle Scholar
  29. 29.
    Torok B, Belagye J, Rietz B, Jacob R. Effectiveness of garlic on the radical activity in radical generating systems. Drug Res 1994; 44: 608–611.Google Scholar
  30. 30.
    Jung EM, Jung F, Mrowietz H, Kieswetter H, Pidndur G, Wenzel E. Influence of garlic powder on cutaneous microcirculation. Drug Res 1991; 41: 626–630.Google Scholar
  31. 31.
    Jung F, Jung EM, Mrowietz C, Kiesewetter H, Wenzel E. Influence of garlic powder on cutaneous microcirculation; a randomised, placebo-controlled, double-blind, crossover study in apparently healthy subjects. Br J Clin Practice 1990; 44(suppl 69): 30–35.Google Scholar
  32. 32.
    Okamoto K, Aoki K. Development of a strain of spontaneously hypertensive rat. Jap Circ J: 1963; 27: 282–293.PubMedGoogle Scholar
  33. 33.
    Bunag RD. Validation in awake rats of a tail-cuff method measuring systolic pressure. J Appl Physiol 1973; 34: 279–282.PubMedGoogle Scholar
  34. 34.
    Whelton PK, Klag MJ. Epidemiology of hypertension. In: Applegate WB, ed. Clinics in Geriatric Medicine: Hypertension. Philadelphia: WB Saunders, 1989, pp. 639–656.Google Scholar
  35. 35.
    DeFronzo RA, Ferinimmi E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173–194.PubMedGoogle Scholar
  36. 36.
    Das I, Khan NS, Soornanna SSR. Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic application. Current Medical Research and Opinion 1994; 13: 257–263.Google Scholar
  37. 37.
    Torok B, Belagyi J, Rietz B, Jacob R. Effectiveness of garlic on the radical activity in radical generating systems. Arzneim-Forsch/Drug Res 1994; 44: 608–611.Google Scholar
  38. 38.
    Sendl A, Schliack M, Losu R, Stanislaus F, Wagner H. Inhibition of cholesterol synthesis in vitro by extracts and isolated compunds prepared from garlic and wild garlic. Atherosclerosis 1992; 94: 79–85.PubMedCrossRefGoogle Scholar
  39. 39.
    Jain RC, Vyas CR. Garlic and alloxan-induced diabetic rabbits. Am J Clin Nutr 1984; 28: 684–685.Google Scholar
  40. 40.
    Sodimu O, Joseph PK, Augusti KT. Certain biological effects of garlic oil on rats maintained on high fat-high cholesterol diet. Experientia 1984; 40: 78–80.PubMedCrossRefGoogle Scholar
  41. 41.
    Aouadi R, Aouidet A, Elkadhi A, Ben Rayana C, Jaafoura H, Tritar B, Nagati K. Effect of fresh garlic (Allium sativum) on lipid metabolism in male rats. Nutr Res 2000; 20: 273–280.CrossRefGoogle Scholar
  42. 42.
    Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chem. Report 1966; 50: 219–239.Google Scholar
  43. 43.
    Pedraza-Chaverri J, Tapia E, Medinal-Campos ON, de los Angeles Granados M, Franco M. Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis. Life Sci 1998; 62: PL 71–77.Google Scholar
  44. 44.
    Das I, Khan NS, Soornanna SSR. Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic application. Current Medical Research and Opinion 1994; 13: 257–263.CrossRefGoogle Scholar
  45. 45.
    Torok B, Belagyi J, Rietz B, Jacob R. Effectiveness of garlic on the radical activity in radical generating systems. Arzneim-Forsch/Drug Res 1994; 44: 608–611.Google Scholar
  46. 46.
    Mohamadi A, Jarrell ST, Shi S-J, Andrawis NS, Myers A, Clouatre D, Preuss HG. Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats. Heat Disease 2000; 2: 3–9.Google Scholar
  47. 47.
    Stevinson C, Pittler MH, Ernst E. Garlic for treating hypercholesterolemia. A meta-analysis of randomized clinical trials. Ann Intern Med 2000; 133: 420–429.PubMedGoogle Scholar
  48. 48.
    Bordia A, Verma SK, Srivastava KC. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 1998; 58: 257–263.PubMedCrossRefGoogle Scholar
  49. 49.
    Rahman K, Billington D. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr 2000; 130: 2662–2665.PubMedGoogle Scholar
  50. 50.
    Tobian L. Human essential hypertension: implications of animal studies. Ann Int Med 1983; 98: 729–734.PubMedGoogle Scholar
  51. 51.
    Preuss HG. Interaction of genetics and nutrition on hypertension. J Am Coll Nutr 1997; 16: 296–305.PubMedGoogle Scholar
  52. 52.
    Freis. ED. Salt, volume, and the prevention of hypertension. Circulation. 1976; 53: 383–387.Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Harry G. Preuss
    • 1
  • Dallas Clouatre
    • 2
  • Ali Mohamadi
    • 1
  • S. Taylor Jarrell
    • 1
  1. 1.Department of PhysiologyGeorgetown University Medical CenterWashington, D.C.USA
  2. 2.Palo AltoUSA

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